Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants
Doxorubicin (DOX) is widely used in the chemotherapy of a wide range of cancers. However, intravenous administration of DOX causes toxicity to most major organs which limits its clinical application. DOX-loaded drug delivery system could provide a continuous sustained-release of drugs and enables hi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1676842 |
| _version_ | 1828770973211426816 |
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| author | Li Gao Qingshan Li Jie Zhang Yixin Huang Lin Deng Chenyang Li Guangping Tai Banfeng Ruan |
| author_facet | Li Gao Qingshan Li Jie Zhang Yixin Huang Lin Deng Chenyang Li Guangping Tai Banfeng Ruan |
| author_sort | Li Gao |
| collection | DOAJ |
| description | Doxorubicin (DOX) is widely used in the chemotherapy of a wide range of cancers. However, intravenous administration of DOX causes toxicity to most major organs which limits its clinical application. DOX-loaded drug delivery system could provide a continuous sustained-release of drugs and enables high drug concentrations at the target site, while reducing systemic toxicity. Additionally, local chemotherapy with DOX may be a promising approach for lowering post-surgical recurrence of cancer. In this study, the sustained-release DOX-loaded implants were prepared by melt-molding method. The implants were characterized with regards to drug content uniformity, micromorphology and drug release profiles. Furthermore, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) analyses were carried out to investigate the drug-excipient compatibility. To determine the local penetration of DOX in liver, the minipigs received intrahepatic implantation of DOX-loaded implants by abdominal surgery. UPLC-MS/MS method was used to detect the concentration of DOX in liver tissues. Our results suggested that DOX-loaded implants delivered high doses of drug at the implantation site for a prolonged period and provided valuable information for the future clinical applications of the DOX-loaded implants. |
| first_indexed | 2024-12-11T14:16:48Z |
| format | Article |
| id | doaj.art-ab189097d3464035b0bb917ce3564f46 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-11T14:16:48Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-ab189097d3464035b0bb917ce3564f462022-12-22T01:03:07ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-012611049105710.1080/10717544.2019.16768421676842Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implantsLi Gao0Qingshan Li1Jie Zhang2Yixin Huang3Lin Deng4Chenyang Li5Guangping Tai6Banfeng Ruan7Hefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei University of TechnologyHefei UniversityHefei UniversityDoxorubicin (DOX) is widely used in the chemotherapy of a wide range of cancers. However, intravenous administration of DOX causes toxicity to most major organs which limits its clinical application. DOX-loaded drug delivery system could provide a continuous sustained-release of drugs and enables high drug concentrations at the target site, while reducing systemic toxicity. Additionally, local chemotherapy with DOX may be a promising approach for lowering post-surgical recurrence of cancer. In this study, the sustained-release DOX-loaded implants were prepared by melt-molding method. The implants were characterized with regards to drug content uniformity, micromorphology and drug release profiles. Furthermore, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) analyses were carried out to investigate the drug-excipient compatibility. To determine the local penetration of DOX in liver, the minipigs received intrahepatic implantation of DOX-loaded implants by abdominal surgery. UPLC-MS/MS method was used to detect the concentration of DOX in liver tissues. Our results suggested that DOX-loaded implants delivered high doses of drug at the implantation site for a prolonged period and provided valuable information for the future clinical applications of the DOX-loaded implants.http://dx.doi.org/10.1080/10717544.2019.1676842doxorubicinimplantsuplc-ms/msminipiglocal penetration |
| spellingShingle | Li Gao Qingshan Li Jie Zhang Yixin Huang Lin Deng Chenyang Li Guangping Tai Banfeng Ruan Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants Drug Delivery doxorubicin implants uplc-ms/ms minipig local penetration |
| title | Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants |
| title_full | Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants |
| title_fullStr | Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants |
| title_full_unstemmed | Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants |
| title_short | Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants |
| title_sort | local penetration of doxorubicin via intrahepatic implantation of plga based doxorubicin loaded implants |
| topic | doxorubicin implants uplc-ms/ms minipig local penetration |
| url | http://dx.doi.org/10.1080/10717544.2019.1676842 |
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