Non-permissive SARS-CoV-2 infection in human neurospheres
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Stem Cell Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612100283X |
| _version_ | 1818847235974103040 |
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| author | Carolina da S.G. Pedrosa Livia Goto-Silva Jairo R. Temerozo Leticia R.Q. Souza Gabriela Vitória Isis M. Ornelas Karina Karmirian Mayara A. Mendes Ismael C. Gomes Carolina Q. Sacramento Natalia Fintelman-Rodrigues Vinicius Cardoso Soares Suelen da Silva Gomes Dias José A. Salerno Teresa Puig-Pijuan Julia T. Oliveira Luiz G.H.S. Aragão Thayana C.Q. Torquato Carla Veríssimo Diogo Biagi Estela M. Cruvinel Rafael Dariolli Daniel R. Furtado Helena L. Borges Patrícia T. Bozza Stevens Rehen Thiago Moreno L. Souza Marília Zaluar P. Guimarães |
| author_facet | Carolina da S.G. Pedrosa Livia Goto-Silva Jairo R. Temerozo Leticia R.Q. Souza Gabriela Vitória Isis M. Ornelas Karina Karmirian Mayara A. Mendes Ismael C. Gomes Carolina Q. Sacramento Natalia Fintelman-Rodrigues Vinicius Cardoso Soares Suelen da Silva Gomes Dias José A. Salerno Teresa Puig-Pijuan Julia T. Oliveira Luiz G.H.S. Aragão Thayana C.Q. Torquato Carla Veríssimo Diogo Biagi Estela M. Cruvinel Rafael Dariolli Daniel R. Furtado Helena L. Borges Patrícia T. Bozza Stevens Rehen Thiago Moreno L. Souza Marília Zaluar P. Guimarães |
| author_sort | Carolina da S.G. Pedrosa |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication. |
| first_indexed | 2024-12-19T05:58:14Z |
| format | Article |
| id | doaj.art-ab1ba8301e984f0faf1cf30367661855 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-19T05:58:14Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-ab1ba8301e984f0faf1cf303676618552022-12-21T20:33:23ZengElsevierStem Cell Research1873-50612021-07-0154102436Non-permissive SARS-CoV-2 infection in human neurospheresCarolina da S.G. Pedrosa0Livia Goto-Silva1Jairo R. Temerozo2Leticia R.Q. Souza3Gabriela Vitória4Isis M. Ornelas5Karina Karmirian6Mayara A. Mendes7Ismael C. Gomes8Carolina Q. Sacramento9Natalia Fintelman-Rodrigues10Vinicius Cardoso Soares11Suelen da Silva Gomes Dias12José A. Salerno13Teresa Puig-Pijuan14Julia T. Oliveira15Luiz G.H.S. Aragão16Thayana C.Q. Torquato17Carla Veríssimo18Diogo Biagi19Estela M. Cruvinel20Rafael Dariolli21Daniel R. Furtado22Helena L. Borges23Patrícia T. Bozza24Stevens Rehen25Thiago Moreno L. Souza26Marília Zaluar P. Guimarães27D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilNational Institute for Science and Technology on Neuroimmunomodulation (INCT/NIM), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Laboratory on Thymus Research, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilInstitute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilImmunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, BrazilImmunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, BrazilImmunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Program of Immunology and Inflammation, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilImmunopharmacology Laboratory, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilInstitute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilPluricell Biotech, São Paulo, SP, BrazilPluricell Biotech, São Paulo, SP, BrazilPluricell Biotech, São Paulo, SP, Brazil; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USAD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, BrazilInstitute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilNational Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, BrazilD’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Corresponding authors at: D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil (S. Rehen and M.Z.P. Guimarães). National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil (T.M.L. Souza).National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil; Program of Immunology and Inflammation, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Corresponding authors at: D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil (S. Rehen and M.Z.P. Guimarães). National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil (T.M.L. Souza).D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Corresponding authors at: D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil (S. Rehen and M.Z.P. Guimarães). National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil (T.M.L. Souza).Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.http://www.sciencedirect.com/science/article/pii/S187350612100283XNew coronavirusBrainNeurospheresSARS-CoV-2iPS |
| spellingShingle | Carolina da S.G. Pedrosa Livia Goto-Silva Jairo R. Temerozo Leticia R.Q. Souza Gabriela Vitória Isis M. Ornelas Karina Karmirian Mayara A. Mendes Ismael C. Gomes Carolina Q. Sacramento Natalia Fintelman-Rodrigues Vinicius Cardoso Soares Suelen da Silva Gomes Dias José A. Salerno Teresa Puig-Pijuan Julia T. Oliveira Luiz G.H.S. Aragão Thayana C.Q. Torquato Carla Veríssimo Diogo Biagi Estela M. Cruvinel Rafael Dariolli Daniel R. Furtado Helena L. Borges Patrícia T. Bozza Stevens Rehen Thiago Moreno L. Souza Marília Zaluar P. Guimarães Non-permissive SARS-CoV-2 infection in human neurospheres Stem Cell Research New coronavirus Brain Neurospheres SARS-CoV-2 iPS |
| title | Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_full | Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_fullStr | Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_full_unstemmed | Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_short | Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_sort | non permissive sars cov 2 infection in human neurospheres |
| topic | New coronavirus Brain Neurospheres SARS-CoV-2 iPS |
| url | http://www.sciencedirect.com/science/article/pii/S187350612100283X |
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