The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg
<p>Abstract</p> <p>Background</p> <p>Cognitive impairment and Alzheimer’s disease (AD) are increasingly considered a major public health problem. The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capaciti...
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | BMC Public Health |
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| Online Access: | http://www.biomedcentral.com/1471-2458/12/519 |
| _version_ | 1811249391719153664 |
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| author | Perquin Magali Schuller Anne-Marie Vaillant Michel Diederich Nico Bisdorff Alexandre Leners Jean-Claude D’Incau Marylène Ludewig Jean-Luc Hoffmann Danielle Ulbricht Dirk Thoma Stephanie Dondelinger René Heuschling Paul Couffignal Sophie Dartigues Jean-François Lair Marie-Lise |
| author_facet | Perquin Magali Schuller Anne-Marie Vaillant Michel Diederich Nico Bisdorff Alexandre Leners Jean-Claude D’Incau Marylène Ludewig Jean-Luc Hoffmann Danielle Ulbricht Dirk Thoma Stephanie Dondelinger René Heuschling Paul Couffignal Sophie Dartigues Jean-François Lair Marie-Lise |
| author_sort | Perquin Magali |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cognitive impairment and Alzheimer’s disease (AD) are increasingly considered a major public health problem. The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (≥ 65 year-old) evolve (1) to mild cognitive impairment (MCI) – transitory non-clinical stage – and (2) to AD. Identifying MCI and AD predictors undeniably constitutes a challenge in public health in that it would allow interventions which could protect or delay the occurrence of cognitive disorders in elderly people. In addition, the MemoVie study sets out to generate hitherto unavailable data, and a comprehensive view of the elderly population in the country.</p> <p>Methods/design</p> <p>The study has been designed with a view to highlighting the prevalence in Luxembourg of MCI and AD in the first step of the survey, conducted among participants selected from a random sample of the general population. A prospective cohort is consequently set up in the second step, and appropriate follow-up of the non-demented participants allows improving the knowledge of the preclinical stage of MCI. Case-control designs are used for cross-sectional or retrospective comparisons between outcomes and biological or clinical factors. To ensure maximal reliability of the information collected, we decided to opt for structured face to face interviews. Besides health status, medical and family history, demographic and socio-cultural information are explored, as well as education, habitat network, social behavior, leisure and physical activities. As multilingualism is expected to challenge the cognitive alterations associated with pathological ageing, it is additionally investigated. Data relative to motor function, including balance, walk, limits of stability, history of falls and accidents are further detailed. Finally, biological examinations, including ApoE genetic polymorphism are carried out. In addition to standard blood parameters, the lipid status of the participants is subsequently determined from the fatty acid profiles in their red blood cells. The study obtained the legal and ethical authorizations.</p> <p>Discussion</p> <p>By means of the multidisciplinary MemoVie study, new insights into the onset of cognitive impairment during aging should be put forward, much to the benefit of intervention strategies as a whole.</p> |
| first_indexed | 2024-04-12T15:45:43Z |
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| id | doaj.art-ab1bafe8974d426a91f128844d1db4e1 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-12T15:45:43Z |
| publishDate | 2012-07-01 |
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| spelling | doaj.art-ab1bafe8974d426a91f128844d1db4e12022-12-22T03:26:40ZengBMCBMC Public Health1471-24582012-07-0112151910.1186/1471-2458-12-519The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, LuxembourgPerquin MagaliSchuller Anne-MarieVaillant MichelDiederich NicoBisdorff AlexandreLeners Jean-ClaudeD’Incau MarylèneLudewig Jean-LucHoffmann DanielleUlbricht DirkThoma StephanieDondelinger RenéHeuschling PaulCouffignal SophieDartigues Jean-FrançoisLair Marie-Lise<p>Abstract</p> <p>Background</p> <p>Cognitive impairment and Alzheimer’s disease (AD) are increasingly considered a major public health problem. The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (≥ 65 year-old) evolve (1) to mild cognitive impairment (MCI) – transitory non-clinical stage – and (2) to AD. Identifying MCI and AD predictors undeniably constitutes a challenge in public health in that it would allow interventions which could protect or delay the occurrence of cognitive disorders in elderly people. In addition, the MemoVie study sets out to generate hitherto unavailable data, and a comprehensive view of the elderly population in the country.</p> <p>Methods/design</p> <p>The study has been designed with a view to highlighting the prevalence in Luxembourg of MCI and AD in the first step of the survey, conducted among participants selected from a random sample of the general population. A prospective cohort is consequently set up in the second step, and appropriate follow-up of the non-demented participants allows improving the knowledge of the preclinical stage of MCI. Case-control designs are used for cross-sectional or retrospective comparisons between outcomes and biological or clinical factors. To ensure maximal reliability of the information collected, we decided to opt for structured face to face interviews. Besides health status, medical and family history, demographic and socio-cultural information are explored, as well as education, habitat network, social behavior, leisure and physical activities. As multilingualism is expected to challenge the cognitive alterations associated with pathological ageing, it is additionally investigated. Data relative to motor function, including balance, walk, limits of stability, history of falls and accidents are further detailed. Finally, biological examinations, including ApoE genetic polymorphism are carried out. In addition to standard blood parameters, the lipid status of the participants is subsequently determined from the fatty acid profiles in their red blood cells. The study obtained the legal and ethical authorizations.</p> <p>Discussion</p> <p>By means of the multidisciplinary MemoVie study, new insights into the onset of cognitive impairment during aging should be put forward, much to the benefit of intervention strategies as a whole.</p>http://www.biomedcentral.com/1471-2458/12/519EpidemiologyPopulation-based studyNested case-control cohortAgingCognitionMild cognitive impairmentAlzheimer’s disease |
| spellingShingle | Perquin Magali Schuller Anne-Marie Vaillant Michel Diederich Nico Bisdorff Alexandre Leners Jean-Claude D’Incau Marylène Ludewig Jean-Luc Hoffmann Danielle Ulbricht Dirk Thoma Stephanie Dondelinger René Heuschling Paul Couffignal Sophie Dartigues Jean-François Lair Marie-Lise The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg BMC Public Health Epidemiology Population-based study Nested case-control cohort Aging Cognition Mild cognitive impairment Alzheimer’s disease |
| title | The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg |
| title_full | The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg |
| title_fullStr | The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg |
| title_full_unstemmed | The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg |
| title_short | The epidemiology of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in community-living seniors: protocol of the MemoVie cohort study, Luxembourg |
| title_sort | epidemiology of mild cognitive impairment mci and alzheimer s disease ad in community living seniors protocol of the memovie cohort study luxembourg |
| topic | Epidemiology Population-based study Nested case-control cohort Aging Cognition Mild cognitive impairment Alzheimer’s disease |
| url | http://www.biomedcentral.com/1471-2458/12/519 |
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