Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages
Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2019-02-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180243 |
| _version_ | 1818967389998415872 |
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| author | Kun Liu Ke Xu Yan Song |
| author_facet | Kun Liu Ke Xu Yan Song |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | Precise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer. However, the molecular basis of timely cell fate/identity specification is only beginning to be understood. In this review, we discuss key regulatory strategies employed in cell fate specification and highlight recent results revealing how timely and robust cell fate/identity commitment is achieved through transcriptional control. |
| first_indexed | 2024-12-20T13:48:02Z |
| format | Article |
| id | doaj.art-ab1c8dad6ab0453d8211c92d58c925c3 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-20T13:48:02Z |
| publishDate | 2019-02-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-ab1c8dad6ab0453d8211c92d58c925c32022-12-21T19:38:35ZengThe Royal SocietyOpen Biology2046-24412019-02-019210.1098/rsob.180243180243Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineagesKun LiuKe XuYan SongPrecise specification of cell fate or identity within stem cell lineages is critical for ensuring correct stem cell lineage progression and tissue homeostasis. Failure to specify cell fate or identity in a timely and robust manner can result in developmental abnormalities and diseases such as cancer. However, the molecular basis of timely cell fate/identity specification is only beginning to be understood. In this review, we discuss key regulatory strategies employed in cell fate specification and highlight recent results revealing how timely and robust cell fate/identity commitment is achieved through transcriptional control.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180243cell fate commitmentdrosophila melanogasterstem cell lineagesamplifierpoisingtimeliness |
| spellingShingle | Kun Liu Ke Xu Yan Song Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages Open Biology cell fate commitment drosophila melanogaster stem cell lineages amplifier poising timeliness |
| title | Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages |
| title_full | Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages |
| title_fullStr | Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages |
| title_full_unstemmed | Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages |
| title_short | Faster, higher, stronger: timely and robust cell fate/identity commitment in stem cell lineages |
| title_sort | faster higher stronger timely and robust cell fate identity commitment in stem cell lineages |
| topic | cell fate commitment drosophila melanogaster stem cell lineages amplifier poising timeliness |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180243 |
| work_keys_str_mv | AT kunliu fasterhigherstrongertimelyandrobustcellfateidentitycommitmentinstemcelllineages AT kexu fasterhigherstrongertimelyandrobustcellfateidentitycommitmentinstemcelllineages AT yansong fasterhigherstrongertimelyandrobustcellfateidentitycommitmentinstemcelllineages |