Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo
Purpose: Vitiligo is a disorder of pigment loss caused by the progressive destruction of melanocytes. The pathophysiology of melanocyte loss has not been fully elucidated today. Oxidative stress is also among the causes. Dynamic thiol/disulfide homeostasis is an essential indicator of the body...
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| Format: | Article |
| Language: | English |
| Published: |
Kirsehir Ahi Evran University
2022-04-01
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| Series: | Ahi Evran Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1783798 |
| Summary: | Purpose: Vitiligo is a disorder of pigment loss caused by the progressive destruction of melanocytes. The pathophysiology of melanocyte loss
has not been fully elucidated today. Oxidative stress is also among the causes. Dynamic thiol/disulfide homeostasis is an essential indicator of
the body's oxidant-antioxidant balance. In this study, we evaluated the thiol/disulfide balance in vitiligo patients compared to healthy individuals.
Materials and Methods: Total thiol and native thiol levels and paraoxonase1 (PON1) activity were measured using a spectrophotometric
method in the serum of 64 patients with vitiligo and 34 healthy individuals. Serum disulfide levels were calculated by calculation.
Results: Total and native thiol levels were higher in the serum of patients with vitiligo compared to healthy individuals (both p<0.001). There
was no statistically significant difference in serum disulfide levels between the two groups.
Conclusion: The thiol/disulfide balance direction has shifted to the thiol direction in patients with vitiligo. Thiol increase may be responsible
for the loss of melanin seen in the pathophysiology of the disease.
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| ISSN: | 2619-9203 |