Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo
Purpose: Vitiligo is a disorder of pigment loss caused by the progressive destruction of melanocytes. The pathophysiology of melanocyte loss has not been fully elucidated today. Oxidative stress is also among the causes. Dynamic thiol/disulfide homeostasis is an essential indicator of the body...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Kirsehir Ahi Evran University
2022-04-01
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| Series: | Ahi Evran Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1783798 |
| _version_ | 1797907659207213056 |
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| author | Bilal İLANBEY Emine Müge ACAR |
| author_facet | Bilal İLANBEY Emine Müge ACAR |
| author_sort | Bilal İLANBEY |
| collection | DOAJ |
| description | Purpose: Vitiligo is a disorder of pigment loss caused by the progressive destruction of melanocytes. The pathophysiology of melanocyte loss
has not been fully elucidated today. Oxidative stress is also among the causes. Dynamic thiol/disulfide homeostasis is an essential indicator of
the body's oxidant-antioxidant balance. In this study, we evaluated the thiol/disulfide balance in vitiligo patients compared to healthy individuals.
Materials and Methods: Total thiol and native thiol levels and paraoxonase1 (PON1) activity were measured using a spectrophotometric
method in the serum of 64 patients with vitiligo and 34 healthy individuals. Serum disulfide levels were calculated by calculation.
Results: Total and native thiol levels were higher in the serum of patients with vitiligo compared to healthy individuals (both p<0.001). There
was no statistically significant difference in serum disulfide levels between the two groups.
Conclusion: The thiol/disulfide balance direction has shifted to the thiol direction in patients with vitiligo. Thiol increase may be responsible
for the loss of melanin seen in the pathophysiology of the disease.
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| first_indexed | 2024-04-10T10:41:24Z |
| format | Article |
| id | doaj.art-ab1cee93eefe467ca09856a7c2814c5e |
| institution | Directory Open Access Journal |
| issn | 2619-9203 |
| language | English |
| last_indexed | 2024-04-10T10:41:24Z |
| publishDate | 2022-04-01 |
| publisher | Kirsehir Ahi Evran University |
| record_format | Article |
| series | Ahi Evran Medical Journal |
| spelling | doaj.art-ab1cee93eefe467ca09856a7c2814c5e2023-02-15T16:20:35ZengKirsehir Ahi Evran UniversityAhi Evran Medical Journal2619-92032022-04-0161939710.46332/aemj.941512Role of Dynamic Thiol/Disulfide Homeostasis in VitiligoBilal İLANBEY0https://orcid.org/0000-0002-7614-281XEmine Müge ACAR1https://orcid.org/0000-0001-9592-5599KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİKIrşehir Eğitim ve Araştırma HastanesiPurpose: Vitiligo is a disorder of pigment loss caused by the progressive destruction of melanocytes. The pathophysiology of melanocyte loss has not been fully elucidated today. Oxidative stress is also among the causes. Dynamic thiol/disulfide homeostasis is an essential indicator of the body's oxidant-antioxidant balance. In this study, we evaluated the thiol/disulfide balance in vitiligo patients compared to healthy individuals. Materials and Methods: Total thiol and native thiol levels and paraoxonase1 (PON1) activity were measured using a spectrophotometric method in the serum of 64 patients with vitiligo and 34 healthy individuals. Serum disulfide levels were calculated by calculation. Results: Total and native thiol levels were higher in the serum of patients with vitiligo compared to healthy individuals (both p<0.001). There was no statistically significant difference in serum disulfide levels between the two groups. Conclusion: The thiol/disulfide balance direction has shifted to the thiol direction in patients with vitiligo. Thiol increase may be responsible for the loss of melanin seen in the pathophysiology of the disease. https://dergipark.org.tr/tr/download/article-file/1783798oxidative stressthiol/disulfide homeostasisvitiligo |
| spellingShingle | Bilal İLANBEY Emine Müge ACAR Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo Ahi Evran Medical Journal oxidative stress thiol/disulfide homeostasis vitiligo |
| title | Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo |
| title_full | Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo |
| title_fullStr | Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo |
| title_full_unstemmed | Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo |
| title_short | Role of Dynamic Thiol/Disulfide Homeostasis in Vitiligo |
| title_sort | role of dynamic thiol disulfide homeostasis in vitiligo |
| topic | oxidative stress thiol/disulfide homeostasis vitiligo |
| url | https://dergipark.org.tr/tr/download/article-file/1783798 |
| work_keys_str_mv | AT bilalilanbey roleofdynamicthioldisulfidehomeostasisinvitiligo AT eminemugeacar roleofdynamicthioldisulfidehomeostasisinvitiligo |