Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection
The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-11-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/9507 |
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| author | Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad Sam Alahyari Malihe Nasiri |
| author_facet | Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad Sam Alahyari Malihe Nasiri |
| author_sort | Ali Asgari |
| collection | DOAJ |
| description | The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests, as well as ROC curves, were used for data analysis. Ninety-eight patients with Corona virus-2 disease (COVID-19), which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU), were evaluated. The mean age in the general wards was lower than in ICU (60.96±14.86 compared to 67.94±16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng/mL compared to 20.57 ng/mL, P=0.003). Furthermore, vitamin D deficiency (25 (OH) D <25 ng/ml) significantly increased the risk of severe disease. (odds ratio=2.91, P=0.019) and mortality (odds ratio=3.64, P=0.026). Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19. Vitamin D levels of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis. |
| first_indexed | 2024-04-11T18:59:57Z |
| format | Article |
| id | doaj.art-ab1d574e7f444d65840b4962744a8b54 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-11T18:59:57Z |
| publishDate | 2021-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-ab1d574e7f444d65840b4962744a8b542022-12-22T04:08:04ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942021-11-01591110.18502/acta.v59i11.77799507Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 InfectionAli Asgari0Ebrahim Hazrati1Saeed Soleiman-Meigooni2Mohsen Rajaeinejad3Sam Alahyari4Malihe Nasiri5Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, IranDepartment of anesthesiology and critical care, AJA University of Medical Sciences, Tehran, IranInfectious Diseases Research Center, AJA University of Medical Sciences, Tehran, IranAJA Cancer Epidemiology Research and Treatment Center (AJA‐ CERTC), AJA University of Medical Sciences, Tehran, IranFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests, as well as ROC curves, were used for data analysis. Ninety-eight patients with Corona virus-2 disease (COVID-19), which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU), were evaluated. The mean age in the general wards was lower than in ICU (60.96±14.86 compared to 67.94±16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng/mL compared to 20.57 ng/mL, P=0.003). Furthermore, vitamin D deficiency (25 (OH) D <25 ng/ml) significantly increased the risk of severe disease. (odds ratio=2.91, P=0.019) and mortality (odds ratio=3.64, P=0.026). Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19. Vitamin D levels of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.https://acta.tums.ac.ir/index.php/acta/article/view/9507Coronavirus disease 2019 (COVID-19)PrognosisRisk factorSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)SeverityVitamin D |
| spellingShingle | Ali Asgari Ebrahim Hazrati Saeed Soleiman-Meigooni Mohsen Rajaeinejad Sam Alahyari Malihe Nasiri Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection Acta Medica Iranica Coronavirus disease 2019 (COVID-19) Prognosis Risk factor Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severity Vitamin D |
| title | Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection |
| title_full | Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection |
| title_fullStr | Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection |
| title_full_unstemmed | Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection |
| title_short | Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients with SARS Corona Virus-2 Infection |
| title_sort | vitamin d insufficiency in disease severity and prognosis of the patients with sars corona virus 2 infection |
| topic | Coronavirus disease 2019 (COVID-19) Prognosis Risk factor Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severity Vitamin D |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/9507 |
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