Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report
Abstract Pulmonary hypoplasia is diagnosed during the perinatal period and is a cause of death in newborns. However, these developmental abnormalities are diagnosed in adulthood in some cases. A 70‐year‐old male smoker was diagnosed with stage IIIA pulmonary adenocarcinoma in the right upper lobe wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14374 |
| _version_ | 1818271853574094848 |
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| author | Takuro Yukawa Yuta Ishida Yoshio Naomoto Yasumasa Monobe Takuya Fukazawa Tomoki Yamatsuji |
| author_facet | Takuro Yukawa Yuta Ishida Yoshio Naomoto Yasumasa Monobe Takuya Fukazawa Tomoki Yamatsuji |
| author_sort | Takuro Yukawa |
| collection | DOAJ |
| description | Abstract Pulmonary hypoplasia is diagnosed during the perinatal period and is a cause of death in newborns. However, these developmental abnormalities are diagnosed in adulthood in some cases. A 70‐year‐old male smoker was diagnosed with stage IIIA pulmonary adenocarcinoma in the right upper lobe with right middle lobe hypoplasia. He subsequently underwent right upper and middle lobectomy with lymph node dissection by video‐assisted thoracoscopic surgery. In addition to an invasive adenocarcinoma in the right upper lobe, pathological examination of the hypoplastic lobe revealed neuroendocrine hyperplasia, as well as tumorlets and a typical carcinoid. Eight cases of pulmonary neuroendocrine tumors that developed from pulmonary hypoplasia have been reported to date. Interestingly, all but one case occurred in the right middle lobe. Neuroendocrine cell hyperplasia has been reported to develop in hypoplastic lungs postnatally; therefore, we speculated that the lesion was the origin of these neuroendocrine tumors. Moreover, the pathological findings suggested that atelectasis was involved in the pathogenesis of this rare condition. In adults, when lobar hypoplasia is diagnosed, neuroendocrine tumors should be anticipated. |
| first_indexed | 2024-12-12T21:32:46Z |
| format | Article |
| id | doaj.art-ab1d78f739604d189061832e705f647c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-12T21:32:46Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-ab1d78f739604d189061832e705f647c2022-12-22T00:11:16ZengWileyThoracic Cancer1759-77061759-77142022-04-011381227123110.1111/1759-7714.14374Neuroendocrine tumor secondary to pulmonary hypoplasia: A case reportTakuro Yukawa0Yuta Ishida1Yoshio Naomoto2Yasumasa Monobe3Takuya Fukazawa4Tomoki Yamatsuji5Department of General Surgery Kawasaki Medical School Okayama JapanDepartment of General Surgery Kawasaki Medical School Okayama JapanDepartment of General Surgery Kawasaki Medical School Okayama JapanDepartment of Pathology 1 Kawasaki Medical School Okayama JapanDepartment of General Surgery Kawasaki Medical School Okayama JapanDepartment of General Surgery Kawasaki Medical School Okayama JapanAbstract Pulmonary hypoplasia is diagnosed during the perinatal period and is a cause of death in newborns. However, these developmental abnormalities are diagnosed in adulthood in some cases. A 70‐year‐old male smoker was diagnosed with stage IIIA pulmonary adenocarcinoma in the right upper lobe with right middle lobe hypoplasia. He subsequently underwent right upper and middle lobectomy with lymph node dissection by video‐assisted thoracoscopic surgery. In addition to an invasive adenocarcinoma in the right upper lobe, pathological examination of the hypoplastic lobe revealed neuroendocrine hyperplasia, as well as tumorlets and a typical carcinoid. Eight cases of pulmonary neuroendocrine tumors that developed from pulmonary hypoplasia have been reported to date. Interestingly, all but one case occurred in the right middle lobe. Neuroendocrine cell hyperplasia has been reported to develop in hypoplastic lungs postnatally; therefore, we speculated that the lesion was the origin of these neuroendocrine tumors. Moreover, the pathological findings suggested that atelectasis was involved in the pathogenesis of this rare condition. In adults, when lobar hypoplasia is diagnosed, neuroendocrine tumors should be anticipated.https://doi.org/10.1111/1759-7714.14374carcinoidneuroendocrine cell hyperplasiapulmonary hypoplasiatumorlet |
| spellingShingle | Takuro Yukawa Yuta Ishida Yoshio Naomoto Yasumasa Monobe Takuya Fukazawa Tomoki Yamatsuji Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report Thoracic Cancer carcinoid neuroendocrine cell hyperplasia pulmonary hypoplasia tumorlet |
| title | Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report |
| title_full | Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report |
| title_fullStr | Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report |
| title_full_unstemmed | Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report |
| title_short | Neuroendocrine tumor secondary to pulmonary hypoplasia: A case report |
| title_sort | neuroendocrine tumor secondary to pulmonary hypoplasia a case report |
| topic | carcinoid neuroendocrine cell hyperplasia pulmonary hypoplasia tumorlet |
| url | https://doi.org/10.1111/1759-7714.14374 |
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