Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors
BackgroundAbnormal hematocrit values, including anemia and polycythemia, are common in patients undergoing craniotomy, but the extent to which preoperative anemia or polycythemia independently increases the risk of mortality is unclear. This retrospective cohort study aimed to examine the associatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1246220/full |
| _version_ | 1797658658699476992 |
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| author | Yangchun Xiao Xin Cheng Lu Jia Yixin Tian Jialing He Miao He Lvlin Chen Pengfei Hao Tiangui Li Weelic Chong Yang Hai Chao You Liyuan Peng Fang Fang Yu Zhang |
| author_facet | Yangchun Xiao Xin Cheng Lu Jia Yixin Tian Jialing He Miao He Lvlin Chen Pengfei Hao Tiangui Li Weelic Chong Yang Hai Chao You Liyuan Peng Fang Fang Yu Zhang |
| author_sort | Yangchun Xiao |
| collection | DOAJ |
| description | BackgroundAbnormal hematocrit values, including anemia and polycythemia, are common in patients undergoing craniotomy, but the extent to which preoperative anemia or polycythemia independently increases the risk of mortality is unclear. This retrospective cohort study aimed to examine the association between preoperative anemia and polycythemia and postoperative mortality in patients who underwent craniotomy for brain tumor resection.MethodsWe retrospectively analyzed data from 12,170 patients diagnosed with a brain tumor who underwent cranial surgery at West China Hospital between January 2011 and March 2021. The preoperative hematocrit value was defined as the last hematocrit value within 7 days before the operation, and patients were grouped according to the severity of their anemia or polycythemia. We assessed the primary outcome of 30-day postoperative mortality using logistic regression analysis adjusted for potential confounding factors.ResultsMultivariable logistic regression analysis reported that the 30-day mortality risk was raised with increasing severity of both anemia and polycythemia. Odds ratios for mild, moderate, and severe anemia were 1.12 (95% CI: 0.79–1.60), 1.66 (95% CI: 1.06–2.58), and 2.24 (95% CI: 0.99–5.06), respectively. Odds ratios for mild, moderate, and severe polycythemia were 1.40 (95% CI: 0.95–2.07), 2.81 (95% CI: 1.32–5.99), and 14.32 (95% CI: 3.84–53.44), respectively.ConclusionsThis study demonstrated that moderate to severe anemia and polycythemia are independently associated with increased postoperative mortality in patients undergoing craniotomy for brain tumor resection. These findings underscore the importance of identifying and managing abnormal hematocrit values before craniotomy surgery. |
| first_indexed | 2024-03-11T18:03:28Z |
| format | Article |
| id | doaj.art-ab210234816d42a0a128a941c65886b2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T18:03:28Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ab210234816d42a0a128a941c65886b22023-10-17T08:49:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12462201246220Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumorsYangchun Xiao0Xin Cheng1Lu Jia2Yixin Tian3Jialing He4Miao He5Lvlin Chen6Pengfei Hao7Tiangui Li8Weelic Chong9Yang Hai10Chao You11Liyuan Peng12Fang Fang13Yu Zhang14Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Anesthesia, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, ChinaDepartment of Neurosurgery, Longquan Hospital, Chengdu, Sichuan, ChinaDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United StatesSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United StatesDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaCenter for Evidence Based Medical, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaBackgroundAbnormal hematocrit values, including anemia and polycythemia, are common in patients undergoing craniotomy, but the extent to which preoperative anemia or polycythemia independently increases the risk of mortality is unclear. This retrospective cohort study aimed to examine the association between preoperative anemia and polycythemia and postoperative mortality in patients who underwent craniotomy for brain tumor resection.MethodsWe retrospectively analyzed data from 12,170 patients diagnosed with a brain tumor who underwent cranial surgery at West China Hospital between January 2011 and March 2021. The preoperative hematocrit value was defined as the last hematocrit value within 7 days before the operation, and patients were grouped according to the severity of their anemia or polycythemia. We assessed the primary outcome of 30-day postoperative mortality using logistic regression analysis adjusted for potential confounding factors.ResultsMultivariable logistic regression analysis reported that the 30-day mortality risk was raised with increasing severity of both anemia and polycythemia. Odds ratios for mild, moderate, and severe anemia were 1.12 (95% CI: 0.79–1.60), 1.66 (95% CI: 1.06–2.58), and 2.24 (95% CI: 0.99–5.06), respectively. Odds ratios for mild, moderate, and severe polycythemia were 1.40 (95% CI: 0.95–2.07), 2.81 (95% CI: 1.32–5.99), and 14.32 (95% CI: 3.84–53.44), respectively.ConclusionsThis study demonstrated that moderate to severe anemia and polycythemia are independently associated with increased postoperative mortality in patients undergoing craniotomy for brain tumor resection. These findings underscore the importance of identifying and managing abnormal hematocrit values before craniotomy surgery.https://www.frontiersin.org/articles/10.3389/fonc.2023.1246220/fullhematocritanemiapolycythemiamortalitybrain tumorcraniotomy |
| spellingShingle | Yangchun Xiao Xin Cheng Lu Jia Yixin Tian Jialing He Miao He Lvlin Chen Pengfei Hao Tiangui Li Weelic Chong Yang Hai Chao You Liyuan Peng Fang Fang Yu Zhang Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors Frontiers in Oncology hematocrit anemia polycythemia mortality brain tumor craniotomy |
| title | Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| title_full | Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| title_fullStr | Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| title_full_unstemmed | Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| title_short | Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| title_sort | preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors |
| topic | hematocrit anemia polycythemia mortality brain tumor craniotomy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1246220/full |
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