Evaluation of laboratory markers of progression of HIV disease to death
INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspar...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2011-12-01
|
| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600001&lng=en&tlng=en |
| _version_ | 1811232548953522176 |
|---|---|
| author | Graça Maria de Castro Viana Maria do Desterro Soares Brandão Nascimento Aila de Menezes Ferreira Érica Milena Fernandes Rabelo João Arnaud Diniz Neto Carolina de Souza Galvão Alessandro Carvalho dos Santos Onildo Martins Santos Júnior Rodrigo Artur Souza de Oliveira José Roberto Binda Júnior |
| author_facet | Graça Maria de Castro Viana Maria do Desterro Soares Brandão Nascimento Aila de Menezes Ferreira Érica Milena Fernandes Rabelo João Arnaud Diniz Neto Carolina de Souza Galvão Alessandro Carvalho dos Santos Onildo Martins Santos Júnior Rodrigo Artur Souza de Oliveira José Roberto Binda Júnior |
| author_sort | Graça Maria de Castro Viana |
| collection | DOAJ |
| description | INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival. |
| first_indexed | 2024-04-12T11:04:45Z |
| format | Article |
| id | doaj.art-ab22c47b30ff41d3a7a26438fd72c6f0 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T11:04:45Z |
| publishDate | 2011-12-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-ab22c47b30ff41d3a7a26438fd72c6f02022-12-22T03:35:50ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492011-12-0144665766010.1590/s0037-86822011005000062S0037-86822011000600001Evaluation of laboratory markers of progression of HIV disease to deathGraça Maria de Castro Viana0Maria do Desterro Soares Brandão Nascimento1Aila de Menezes Ferreira2Érica Milena Fernandes Rabelo3João Arnaud Diniz Neto4Carolina de Souza Galvão5Alessandro Carvalho dos Santos6Onildo Martins Santos Júnior7Rodrigo Artur Souza de Oliveira8José Roberto Binda Júnior9Universidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoUniversidade CEUMAINTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600001&lng=en&tlng=enFatores de riscoPrognósticoHIV/AIDS |
| spellingShingle | Graça Maria de Castro Viana Maria do Desterro Soares Brandão Nascimento Aila de Menezes Ferreira Érica Milena Fernandes Rabelo João Arnaud Diniz Neto Carolina de Souza Galvão Alessandro Carvalho dos Santos Onildo Martins Santos Júnior Rodrigo Artur Souza de Oliveira José Roberto Binda Júnior Evaluation of laboratory markers of progression of HIV disease to death Revista da Sociedade Brasileira de Medicina Tropical Fatores de risco Prognóstico HIV/AIDS |
| title | Evaluation of laboratory markers of progression of HIV disease to death |
| title_full | Evaluation of laboratory markers of progression of HIV disease to death |
| title_fullStr | Evaluation of laboratory markers of progression of HIV disease to death |
| title_full_unstemmed | Evaluation of laboratory markers of progression of HIV disease to death |
| title_short | Evaluation of laboratory markers of progression of HIV disease to death |
| title_sort | evaluation of laboratory markers of progression of hiv disease to death |
| topic | Fatores de risco Prognóstico HIV/AIDS |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000600001&lng=en&tlng=en |
| work_keys_str_mv | AT gracamariadecastroviana evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT mariadodesterrosoaresbrandaonascimento evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT ailademenezesferreira evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT ericamilenafernandesrabelo evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT joaoarnauddinizneto evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT carolinadesouzagalvao evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT alessandrocarvalhodossantos evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT onildomartinssantosjunior evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT rodrigoartursouzadeoliveira evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath AT joserobertobindajunior evaluationoflaboratorymarkersofprogressionofhivdiseasetodeath |