Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury
Objective Acute spinal cord injury (SCI) can result in debilitating motor, sensory, and autonomic dysfunction. As a treatment option, therapeutic hypothermia has been researched to inadequate pharmaceutical treatment, except for methylprednisolone. In this article, we systematically meta-analyzed to...
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| Format: | Article |
| Language: | English |
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Korean Spinal Neurosurgery Society
2022-09-01
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| Series: | Neurospine |
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| Online Access: | http://e-neurospine.org/upload/pdf/ns-2244444-222.pdf |
| _version_ | 1797329812598030336 |
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| author | Hong Kyung Shin Jin Hoon Park Sung Woo Roh Sang Ryong Jeon |
| author_facet | Hong Kyung Shin Jin Hoon Park Sung Woo Roh Sang Ryong Jeon |
| author_sort | Hong Kyung Shin |
| collection | DOAJ |
| description | Objective Acute spinal cord injury (SCI) can result in debilitating motor, sensory, and autonomic dysfunction. As a treatment option, therapeutic hypothermia has been researched to inadequate pharmaceutical treatment, except for methylprednisolone. In this article, we systematically meta-analyzed to clarify the effect of hypothermia in acute SCI on neurological outcomes. Methods The PubMed, Embase, Web of Science, and Cochrane clinical trial databases were systematically searched until June 30, 2022. The proportion of cases with improved neurological status after hypothermia in acute SCI were pooled with a random-effects model. Subgroup analyses for the method of hypothermia and injury level were conducted. Results Eight studies with a total of 103 patients were included. Hypothermia in acute SCI improved neurological function by 55.8% (95% confidence interval [CI]: 39.4%–72.1%). The subgroup analysis revealed that the pooled proportion of cases showing neurological improvement was higher with systemic hypothermia (70.9%) (95% CI, 14.9%–100%) than with local hypothermia (52.5%) (95% CI, 40.4%–64.5%), although the subgroup difference was not statistically significant (p=0.53). Another subgroup analysis revealed that the proportion of cases with neurological improvement did not differ statistically between the cervical spine (61.4%) (95% CI, 42.2%–80.6%) and thoracic spine injury groups (59.4%) (95% CI, 34.8%–84.0%) (p=0.90). Conclusion This meta-analysis identified that more than 50% of patients showed neurological improvement after hypothermia following acute SCI in general. A multicenter, randomized, double-blind study with larger sample size is necessary to validate the findings further. |
| first_indexed | 2024-03-08T07:11:49Z |
| format | Article |
| id | doaj.art-ab22c5239fd94c308173b7a9c4195c88 |
| institution | Directory Open Access Journal |
| issn | 2586-6583 2586-6591 |
| language | English |
| last_indexed | 2024-03-08T07:11:49Z |
| publishDate | 2022-09-01 |
| publisher | Korean Spinal Neurosurgery Society |
| record_format | Article |
| series | Neurospine |
| spelling | doaj.art-ab22c5239fd94c308173b7a9c4195c882024-02-03T02:47:19ZengKorean Spinal Neurosurgery SocietyNeurospine2586-65832586-65912022-09-0119374875610.14245/ns.2244444.2221302Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord InjuryHong Kyung Shin0Jin Hoon Park1Sung Woo Roh2Sang Ryong Jeon Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaObjective Acute spinal cord injury (SCI) can result in debilitating motor, sensory, and autonomic dysfunction. As a treatment option, therapeutic hypothermia has been researched to inadequate pharmaceutical treatment, except for methylprednisolone. In this article, we systematically meta-analyzed to clarify the effect of hypothermia in acute SCI on neurological outcomes. Methods The PubMed, Embase, Web of Science, and Cochrane clinical trial databases were systematically searched until June 30, 2022. The proportion of cases with improved neurological status after hypothermia in acute SCI were pooled with a random-effects model. Subgroup analyses for the method of hypothermia and injury level were conducted. Results Eight studies with a total of 103 patients were included. Hypothermia in acute SCI improved neurological function by 55.8% (95% confidence interval [CI]: 39.4%–72.1%). The subgroup analysis revealed that the pooled proportion of cases showing neurological improvement was higher with systemic hypothermia (70.9%) (95% CI, 14.9%–100%) than with local hypothermia (52.5%) (95% CI, 40.4%–64.5%), although the subgroup difference was not statistically significant (p=0.53). Another subgroup analysis revealed that the proportion of cases with neurological improvement did not differ statistically between the cervical spine (61.4%) (95% CI, 42.2%–80.6%) and thoracic spine injury groups (59.4%) (95% CI, 34.8%–84.0%) (p=0.90). Conclusion This meta-analysis identified that more than 50% of patients showed neurological improvement after hypothermia following acute SCI in general. A multicenter, randomized, double-blind study with larger sample size is necessary to validate the findings further.http://e-neurospine.org/upload/pdf/ns-2244444-222.pdfacutehypothermiameta-analysisspinal cord injury |
| spellingShingle | Hong Kyung Shin Jin Hoon Park Sung Woo Roh Sang Ryong Jeon Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury Neurospine acute hypothermia meta-analysis spinal cord injury |
| title | Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury |
| title_full | Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury |
| title_fullStr | Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury |
| title_full_unstemmed | Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury |
| title_short | Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury |
| title_sort | meta analysis on the effect of hypothermia in acute spinal cord injury |
| topic | acute hypothermia meta-analysis spinal cord injury |
| url | http://e-neurospine.org/upload/pdf/ns-2244444-222.pdf |
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