Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial
Background The treatment of atrophic acne scars represents a therapeutic challenge. Recently, plasma gel has been introduced among treatment modalities. Objective To compare the efficacy of platelet-rich-plasma ‘fluid’ versus ‘gel’ form combined with fractional CO2 laser in the treatment of atrophic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2022.2067816 |
| _version_ | 1797683490145173504 |
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| author | Heba I. Gawdat Yasmin Ahmed El-Hadidy Riham S. H. M. Allam Heba Ahmed Abdelkader |
| author_facet | Heba I. Gawdat Yasmin Ahmed El-Hadidy Riham S. H. M. Allam Heba Ahmed Abdelkader |
| author_sort | Heba I. Gawdat |
| collection | DOAJ |
| description | Background The treatment of atrophic acne scars represents a therapeutic challenge. Recently, plasma gel has been introduced among treatment modalities. Objective To compare the efficacy of platelet-rich-plasma ‘fluid’ versus ‘gel’ form combined with fractional CO2 laser in the treatment of atrophic acne scars. Methods Twenty-seven patients with atrophic acne scars were included. Treatment with fractional CO2 laser plus plasma fluid/gel was randomly assigned to the right/left sides of the face. Clinical and Optical Coherence Tomography (OCT) assessments were scheduled at baseline, one month, and three months after the last session. Results There was a significant improvement in clinical assessment scores at third-month follow-up on the plasma gel- and plasma fluid-treated sides compared to those at the first-month follow-up (p < .001). Scar depth decreased significantly at third-month follow-up when compared to baseline on both plasma gel- and plasma fluid-treated sides (p < .001). The numerical pain score was significantly lower on the plasma fluid-treated side compared to the plasma gel-treated side (p = .004). Conclusion The use of platelet-rich plasma in combination with fractional CO2 laser, both in fluid and gel form, produced significant results in the treatment of atrophic acne scars. Patients reported an immediate more noticeable effect with plasma gel. However, the fluid injection was less painful. |
| first_indexed | 2024-03-12T00:16:12Z |
| format | Article |
| id | doaj.art-ab238d2206424f7ea1f99f482f7f91bc |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:12Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-ab238d2206424f7ea1f99f482f7f91bc2023-09-15T14:28:51ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352654266310.1080/09546634.2022.20678162067816Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trialHeba I. Gawdat0Yasmin Ahmed El-Hadidy1Riham S. H. M. Allam2Heba Ahmed Abdelkader3Department of Dermatology, Faculty of Medicine, Cairo UniversityDepartment of Dermatology, Faculty of Medicine, Cairo UniversityDepartment of Ophthalmology, Faculty of Medicine, Cairo UniversityDepartment of Dermatology, Faculty of Medicine, Cairo UniversityBackground The treatment of atrophic acne scars represents a therapeutic challenge. Recently, plasma gel has been introduced among treatment modalities. Objective To compare the efficacy of platelet-rich-plasma ‘fluid’ versus ‘gel’ form combined with fractional CO2 laser in the treatment of atrophic acne scars. Methods Twenty-seven patients with atrophic acne scars were included. Treatment with fractional CO2 laser plus plasma fluid/gel was randomly assigned to the right/left sides of the face. Clinical and Optical Coherence Tomography (OCT) assessments were scheduled at baseline, one month, and three months after the last session. Results There was a significant improvement in clinical assessment scores at third-month follow-up on the plasma gel- and plasma fluid-treated sides compared to those at the first-month follow-up (p < .001). Scar depth decreased significantly at third-month follow-up when compared to baseline on both plasma gel- and plasma fluid-treated sides (p < .001). The numerical pain score was significantly lower on the plasma fluid-treated side compared to the plasma gel-treated side (p = .004). Conclusion The use of platelet-rich plasma in combination with fractional CO2 laser, both in fluid and gel form, produced significant results in the treatment of atrophic acne scars. Patients reported an immediate more noticeable effect with plasma gel. However, the fluid injection was less painful.http://dx.doi.org/10.1080/09546634.2022.2067816acne scarsplatelet-rich plasmaplasma gelfractional co2 laser |
| spellingShingle | Heba I. Gawdat Yasmin Ahmed El-Hadidy Riham S. H. M. Allam Heba Ahmed Abdelkader Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial Journal of Dermatological Treatment acne scars platelet-rich plasma plasma gel fractional co2 laser |
| title | Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial |
| title_full | Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial |
| title_fullStr | Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial |
| title_full_unstemmed | Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial |
| title_short | Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial |
| title_sort | autologous platelet rich plasma fluid versus gel form in combination with fractional co2 laser in the treatment of atrophic acne scars a split face randomized clinical trial |
| topic | acne scars platelet-rich plasma plasma gel fractional co2 laser |
| url | http://dx.doi.org/10.1080/09546634.2022.2067816 |
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