Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan
AimStudies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.MethodsIn this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.561420/full |
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| author | Fu-Hsiung Su Fu-Hsiung Su Fu-Hsiung Su Chyi-Huey Bai Thi Nga Le Chih-Hsin Muo Shih-Ni Chang Shih-Ni Chang Arlene Te Arlene Te Fung-Chang Sung Fung-Chang Sung Fung-Chang Sung Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh |
| author_facet | Fu-Hsiung Su Fu-Hsiung Su Fu-Hsiung Su Chyi-Huey Bai Thi Nga Le Chih-Hsin Muo Shih-Ni Chang Shih-Ni Chang Arlene Te Arlene Te Fung-Chang Sung Fung-Chang Sung Fung-Chang Sung Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh |
| author_sort | Fu-Hsiung Su |
| collection | DOAJ |
| description | AimStudies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.MethodsIn this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases.ResultsResults of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.ConclusionsOur findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients. |
| first_indexed | 2024-12-20T14:03:15Z |
| format | Article |
| id | doaj.art-ab23b38d0cf8444f91a9d95a8ea92d67 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T14:03:15Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ab23b38d0cf8444f91a9d95a8ea92d672022-12-21T19:38:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.561420561420Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in TaiwanFu-Hsiung Su0Fu-Hsiung Su1Fu-Hsiung Su2Chyi-Huey Bai3Thi Nga Le4Chih-Hsin Muo5Shih-Ni Chang6Shih-Ni Chang7Arlene Te8Arlene Te9Fung-Chang Sung10Fung-Chang Sung11Fung-Chang Sung12Chih-Ching Yeh13Chih-Ching Yeh14Chih-Ching Yeh15Chih-Ching Yeh16Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanInternational Master/PhD Program, College of Medicine, Taipei Medical University, Taipei City, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanBig Data Center, China Medical University Hospital, Taichung, TaiwanThe Ph.D. Program for Cancer Biology and Drug Discovery, School of Medicine, China Medical University, Taichung, TaiwanDepartment of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanDepartment of Health Services Administration, College of Public Health, China Medical University, Taichung, TaiwanDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan0Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan1Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan2Master Program in Applied Molecular Epidemiology, College of Public Health, Taipei Medical University, Taipei, TaiwanAimStudies evaluating colorectal cancer (CRC) risk associated with chronic hepatitis C virus (HCV) infection are limited.MethodsIn this case-control study, we identify 67,670 CRC cases newly diagnosed from 2005 to 2011 and randomly selected 67,670 controls without HCV and CRC from the same database, frequency matched by age and sex of cases.ResultsResults of logistic regression analysis revealed that the adjusted odds ratio (aOR) of CRC was 1.16 (95% confidence interval [CI] = 1.08–1.24, p < 0.001) in association with chronic HCV. The CRC risk was slightly greater for women than for men. The risk decreased with age, with the aOR decreased from 2.26 (95% CI = 1.32–3.87, p = 0.003) in patients under 45 years old to 1.31 (95% CI = 1.10–1.55, p = 0.03) in patients aged 50–59, and 1.10 (95% CI = 1.00–1.22, p = 0.061) in patients aged over 70.ConclusionsOur findings suggested that patients with chronic HCV infection are at an elevated risk of developing CRC. Our data also imply that the CRC prevention programs are needed to target younger HCV patients.https://www.frontiersin.org/articles/10.3389/fonc.2020.561420/fullhepatitis C viruscolorectal cancerpopulation-basedcase-control studyinsurance data |
| spellingShingle | Fu-Hsiung Su Fu-Hsiung Su Fu-Hsiung Su Chyi-Huey Bai Thi Nga Le Chih-Hsin Muo Shih-Ni Chang Shih-Ni Chang Arlene Te Arlene Te Fung-Chang Sung Fung-Chang Sung Fung-Chang Sung Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh Chih-Ching Yeh Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan Frontiers in Oncology hepatitis C virus colorectal cancer population-based case-control study insurance data |
| title | Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan |
| title_full | Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan |
| title_fullStr | Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan |
| title_full_unstemmed | Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan |
| title_short | Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan |
| title_sort | patients with chronic hepatitis c virus infection are at an increased risk of colorectal cancer a nationwide population based case control study in taiwan |
| topic | hepatitis C virus colorectal cancer population-based case-control study insurance data |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.561420/full |
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