Vasculature-On-A-Chip for In Vitro Disease Models
Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-01-01
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| Series: | Bioengineering |
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| Online Access: | http://www.mdpi.com/2306-5354/4/1/8 |
| _version_ | 1797757631236931584 |
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| author | Seunggyu Kim Wanho Kim Seongjin Lim Jessie S. Jeon |
| author_facet | Seunggyu Kim Wanho Kim Seongjin Lim Jessie S. Jeon |
| author_sort | Seunggyu Kim |
| collection | DOAJ |
| description | Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularization process so that in vitro recapitulation of vascularization is possible. The current microfluidic systems allow elaborative research on the effects of various cues for vascularization, and furthermore, in vitro technologies have a great potential for being applied to the vascular disease models for studying pathological events and developing drug screening platforms. Here, we review methods of fabrication for microfluidic assays and inducing factors for vascularization. We also discuss applications using engineered vasculature such as in vitro vascular disease models, vasculature in organ-on-chips and drug screening platforms. |
| first_indexed | 2024-03-12T18:18:27Z |
| format | Article |
| id | doaj.art-ab24169e87d04148b9a95da11c829114 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T18:18:27Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-ab24169e87d04148b9a95da11c8291142023-08-02T09:01:19ZengMDPI AGBioengineering2306-53542017-01-0141810.3390/bioengineering4010008bioengineering4010008Vasculature-On-A-Chip for In Vitro Disease ModelsSeunggyu Kim0Wanho Kim1Seongjin Lim2Jessie S. Jeon3Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, KoreaDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, KoreaDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, KoreaDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, KoreaVascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularization process so that in vitro recapitulation of vascularization is possible. The current microfluidic systems allow elaborative research on the effects of various cues for vascularization, and furthermore, in vitro technologies have a great potential for being applied to the vascular disease models for studying pathological events and developing drug screening platforms. Here, we review methods of fabrication for microfluidic assays and inducing factors for vascularization. We also discuss applications using engineered vasculature such as in vitro vascular disease models, vasculature in organ-on-chips and drug screening platforms.http://www.mdpi.com/2306-5354/4/1/8vasculature-on-a-chipangiogenesismicrofluidicsin vitro disease models |
| spellingShingle | Seunggyu Kim Wanho Kim Seongjin Lim Jessie S. Jeon Vasculature-On-A-Chip for In Vitro Disease Models Bioengineering vasculature-on-a-chip angiogenesis microfluidics in vitro disease models |
| title | Vasculature-On-A-Chip for In Vitro Disease Models |
| title_full | Vasculature-On-A-Chip for In Vitro Disease Models |
| title_fullStr | Vasculature-On-A-Chip for In Vitro Disease Models |
| title_full_unstemmed | Vasculature-On-A-Chip for In Vitro Disease Models |
| title_short | Vasculature-On-A-Chip for In Vitro Disease Models |
| title_sort | vasculature on a chip for in vitro disease models |
| topic | vasculature-on-a-chip angiogenesis microfluidics in vitro disease models |
| url | http://www.mdpi.com/2306-5354/4/1/8 |
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