Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma
Yong-Jiang Li, Xi Yang, Wen-Biao Zhang, Cheng Yi, Feng Wang, Ping Li Department of Oncology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Abstract: Cancer-related systemic inflammation responses have been correlat...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/clinical-implications-of-six-inflammatory-biomarkers-as-prognostic-ind-peer-reviewed-article-CMAR |
| _version_ | 1819089911023665152 |
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| author | Li YJ Yang X Zhang WB Yi C Wang F Li P |
| author_facet | Li YJ Yang X Zhang WB Yi C Wang F Li P |
| author_sort | Li YJ |
| collection | DOAJ |
| description | Yong-Jiang Li, Xi Yang, Wen-Biao Zhang, Cheng Yi, Feng Wang, Ping Li Department of Oncology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Abstract: Cancer-related systemic inflammation responses have been correlated with cancer development and progression. The prognostic significance of several inflammatory indicators, including neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), C-reactive protein to albumin ratio (CRP/Alb ratio), lymphocyte–monocyte ratio (LMR), and neutrophil–platelet score (NPS), were found to be correlated with prognosis in several cancers. However, the prognostic role of these inflammatory biomarkers in Ewing sarcoma has not been evaluated. This study enrolled 122 Ewing patients. Receiver operating characteristic (ROC) analysis was generated to determine optimal cutoff values; areas under the curves (AUCs) were assessed to show the discriminatory ability of the biomarkers; Kaplan–Meier analysis was conducted to plot the survival curves; and Cox multivariate survival analysis was performed to identify independent prognostic factors. The optimal cutoff values of CRP/Alb ratio, NLR, PLR, and LMR were 0.225, 2.38, 131, and 4.41, respectively. CRP/Alb ratio had a significantly larger AUC than NLR, PLR, LMR, and NPS. Higher levels of CRP/Alb ratio (hazard ratio [HR] 2.41, P=0.005), GPS (HR 2.27, P=0.006), NLR (HR 2.07, P=0.013), and PLR (HR 1.85, P=0.032) were significantly correlated with poor prognosis. As the biomarkers had internal correlations, only the CRP/Alb ratio was involved in the multivariate Cox analysis and remained an independent prognostic indicator. The study demonstrated that CRP/Alb ratio, GPS, and NLR were effective prognostic indicators for patients with Ewing sarcoma, and the CRP/Alb ratio was the most robust prognostic indicator with a discriminatory ability superior to that of the other indicators; however, PLR, LMR, and NPS may not be suitable as prognostic indicators in Ewing sarcoma. Keywords: Ewing sarcoma, inflammatory biomarkers, prognosis, survival, CRP/Alb ratio |
| first_indexed | 2024-12-21T22:15:27Z |
| format | Article |
| id | doaj.art-ab243f8955d34195bc7e2a482d101f9b |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-21T22:15:27Z |
| publishDate | 2017-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-ab243f8955d34195bc7e2a482d101f9b2022-12-21T18:48:28ZengDove Medical PressCancer Management and Research1179-13222017-09-01Volume 944345134930Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcomaLi YJYang XZhang WBYi CWang FLi PYong-Jiang Li, Xi Yang, Wen-Biao Zhang, Cheng Yi, Feng Wang, Ping Li Department of Oncology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Abstract: Cancer-related systemic inflammation responses have been correlated with cancer development and progression. The prognostic significance of several inflammatory indicators, including neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), C-reactive protein to albumin ratio (CRP/Alb ratio), lymphocyte–monocyte ratio (LMR), and neutrophil–platelet score (NPS), were found to be correlated with prognosis in several cancers. However, the prognostic role of these inflammatory biomarkers in Ewing sarcoma has not been evaluated. This study enrolled 122 Ewing patients. Receiver operating characteristic (ROC) analysis was generated to determine optimal cutoff values; areas under the curves (AUCs) were assessed to show the discriminatory ability of the biomarkers; Kaplan–Meier analysis was conducted to plot the survival curves; and Cox multivariate survival analysis was performed to identify independent prognostic factors. The optimal cutoff values of CRP/Alb ratio, NLR, PLR, and LMR were 0.225, 2.38, 131, and 4.41, respectively. CRP/Alb ratio had a significantly larger AUC than NLR, PLR, LMR, and NPS. Higher levels of CRP/Alb ratio (hazard ratio [HR] 2.41, P=0.005), GPS (HR 2.27, P=0.006), NLR (HR 2.07, P=0.013), and PLR (HR 1.85, P=0.032) were significantly correlated with poor prognosis. As the biomarkers had internal correlations, only the CRP/Alb ratio was involved in the multivariate Cox analysis and remained an independent prognostic indicator. The study demonstrated that CRP/Alb ratio, GPS, and NLR were effective prognostic indicators for patients with Ewing sarcoma, and the CRP/Alb ratio was the most robust prognostic indicator with a discriminatory ability superior to that of the other indicators; however, PLR, LMR, and NPS may not be suitable as prognostic indicators in Ewing sarcoma. Keywords: Ewing sarcoma, inflammatory biomarkers, prognosis, survival, CRP/Alb ratiohttps://www.dovepress.com/clinical-implications-of-six-inflammatory-biomarkers-as-prognostic-ind-peer-reviewed-article-CMAREwing sarcomaInflammatory biomarkersPrognosisSurvivalCRP/Alb ratio |
| spellingShingle | Li YJ Yang X Zhang WB Yi C Wang F Li P Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma Cancer Management and Research Ewing sarcoma Inflammatory biomarkers Prognosis Survival CRP/Alb ratio |
| title | Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma |
| title_full | Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma |
| title_fullStr | Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma |
| title_full_unstemmed | Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma |
| title_short | Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma |
| title_sort | clinical implications of six inflammatory biomarkers as prognostic indicators in ewing sarcoma |
| topic | Ewing sarcoma Inflammatory biomarkers Prognosis Survival CRP/Alb ratio |
| url | https://www.dovepress.com/clinical-implications-of-six-inflammatory-biomarkers-as-prognostic-ind-peer-reviewed-article-CMAR |
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