Superiority of focused ion beam‐scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity

Superiority of focused ion beam‐scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity

Abstract Background Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostl...

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Bibliographic Details
Main Authors: Jacqueline Heinen‐Weiler, Mike Hasenberg, Martin Heisler, Stephan Settelmeier, Anna‐Lena Beerlage, Hannah Doepper, Bernd Walkenfort, Andrea Odersky, Peter Luedike, Elke Winterhager, Tienush Rassaf, Ulrike B. Hendgen‐Cotta
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cardiac mitochondria
Focused ion beam‐scanning electron microscopy
BNIP3
3D morphometry
Mitochondrial energetics
Mitochondrial dynamics
Online Access:https://doi.org/10.1002/jcsm.12742

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