Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts
Aging is a natural process in human that can be characterized by the appearance of black spot on the skin due to hyperpigmentation. Aging may occur due to an excessive amount of free radicals in the body. Antioxidants possess ability to capture free radicals and inhibit tyrosinase which induces skin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Islam Bandung
2020-01-01
|
| Series: | Global Medical & Health Communication |
| Subjects: | |
| Online Access: | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/4453 |
| _version_ | 1818943207230144512 |
|---|---|
| author | Sonya Bonifacia Mahadi Rr. Anisa Siwianti Handayani Wahyu Widowati Wilsen Wilsen Yunita Dewani Edy Fachrial I Nyoman Ehrich Lister |
| author_facet | Sonya Bonifacia Mahadi Rr. Anisa Siwianti Handayani Wahyu Widowati Wilsen Wilsen Yunita Dewani Edy Fachrial I Nyoman Ehrich Lister |
| author_sort | Sonya Bonifacia Mahadi |
| collection | DOAJ |
| description | Aging is a natural process in human that can be characterized by the appearance of black spot on the skin due to hyperpigmentation. Aging may occur due to an excessive amount of free radicals in the body. Antioxidants possess ability to capture free radicals and inhibit tyrosinase which induces skin aging. Aloe vera has been used in traditional medicine because it contains several bioactive compounds that act as antioxidant and prevent aging process. This study aims to determine phytochemical content, antioxidant activity and tyrosinase inhibition activity of Aloe vera rind (AVRE) and gel (AVGE) extract. This research was carried out at Aretha Medika Utama-Biomolecular and Biomedical Research Center in Bandung city in September-November 2018. Phytochemical assay was determined using modified Farnsworth method. Antioxidant assay was determined using DPPH scavenging activity and antiaging assay was obtained using tyrosinase inhibition assay. AVRE contains flavonoid, phenol, steroid, and alkaloid. Meanwhile, AVGE contains steroid and alkaloid. IC50 DPPH scavenging activity of AVRE was 113.18 µg/mL followed by AVGE was 291.96 µg/mL. IC50 tyrosinase inhibition activity of AVRE was 65.04 µg/mL followed by AVGE was 111.89 µg/mL. AVRE had more active DPPH scavenging activity and tyrosinase inhibition activity than AVGE. |
| first_indexed | 2024-12-20T07:23:39Z |
| format | Article |
| id | doaj.art-ab25a5b347574432966a0e34c33de449 |
| institution | Directory Open Access Journal |
| issn | 2301-9123 2460-5441 |
| language | English |
| last_indexed | 2024-12-20T07:23:39Z |
| publishDate | 2020-01-01 |
| publisher | Universitas Islam Bandung |
| record_format | Article |
| series | Global Medical & Health Communication |
| spelling | doaj.art-ab25a5b347574432966a0e34c33de4492022-12-21T19:48:37ZengUniversitas Islam BandungGlobal Medical & Health Communication2301-91232460-54412020-01-017310.29313/gmhc.v7i3.44533094Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel ExtractsSonya Bonifacia Mahadi0Rr. Anisa Siwianti Handayani1Wahyu Widowati2Wilsen Wilsen3Yunita Dewani4Edy Fachrial5I Nyoman Ehrich Lister6Master in Biomedical Science, Faculty of Medicine, Universitas Prima Indonesia Jalan Belanga No. 1 simp. Ayahanda, Medan-20118, North Sumatera, IndonesiaBiomolecular and Biomedical Research Center, Aretha Medika Utama Jl. Babakan Jeruk II No. 9, Sukagalih, Sukajadi, Bandung-40163, West Java, IndonesiaFaculty of Medicine, Maranatha Christian University Jl. Prof. drg. Surya Sumantri, M.P.H. No. 65, Bandung-40164, West Java, IndonesiaFaculty of Medicine, Universitas Prima Indonesia Jalan Belanga No. 1 simp. Ayahanda, Medan-20118, North Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia Jalan Belanga No. 1 simp. Ayahanda, Medan-20118, North Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia Jalan Belanga No. 1 simp. Ayahanda, Medan-20118, North Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia Jalan Belanga No. 1 simp. Ayahanda, Medan-20118, North Sumatera, IndonesiaAging is a natural process in human that can be characterized by the appearance of black spot on the skin due to hyperpigmentation. Aging may occur due to an excessive amount of free radicals in the body. Antioxidants possess ability to capture free radicals and inhibit tyrosinase which induces skin aging. Aloe vera has been used in traditional medicine because it contains several bioactive compounds that act as antioxidant and prevent aging process. This study aims to determine phytochemical content, antioxidant activity and tyrosinase inhibition activity of Aloe vera rind (AVRE) and gel (AVGE) extract. This research was carried out at Aretha Medika Utama-Biomolecular and Biomedical Research Center in Bandung city in September-November 2018. Phytochemical assay was determined using modified Farnsworth method. Antioxidant assay was determined using DPPH scavenging activity and antiaging assay was obtained using tyrosinase inhibition assay. AVRE contains flavonoid, phenol, steroid, and alkaloid. Meanwhile, AVGE contains steroid and alkaloid. IC50 DPPH scavenging activity of AVRE was 113.18 µg/mL followed by AVGE was 291.96 µg/mL. IC50 tyrosinase inhibition activity of AVRE was 65.04 µg/mL followed by AVGE was 111.89 µg/mL. AVRE had more active DPPH scavenging activity and tyrosinase inhibition activity than AVGE.https://ejournal.unisba.ac.id/index.php/gmhc/article/view/4453aloe vera, antioxidants, anti-tyrosinase, dpph |
| spellingShingle | Sonya Bonifacia Mahadi Rr. Anisa Siwianti Handayani Wahyu Widowati Wilsen Wilsen Yunita Dewani Edy Fachrial I Nyoman Ehrich Lister Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts Global Medical & Health Communication aloe vera, antioxidants, anti-tyrosinase, dpph |
| title | Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts |
| title_full | Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts |
| title_fullStr | Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts |
| title_full_unstemmed | Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts |
| title_short | Antioxidant and Anti-Tyrosinase Activities of Aloe vera Rind and Gel Extracts |
| title_sort | antioxidant and anti tyrosinase activities of aloe vera rind and gel extracts |
| topic | aloe vera, antioxidants, anti-tyrosinase, dpph |
| url | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/4453 |
| work_keys_str_mv | AT sonyabonifaciamahadi antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT rranisasiwiantihandayani antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT wahyuwidowati antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT wilsenwilsen antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT yunitadewani antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT edyfachrial antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts AT inyomanehrichlister antioxidantandantityrosinaseactivitiesofaloeverarindandgelextracts |