Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis
Objective: The key element in the pathogenesis of systemic sclerosis (SSc) is microcirculatory changes in several vascular beds. Uric acid is associated with endothelial dysfunction and therefore, microvascular damage. The aim of this study was to examine the association between uric acid (UA) and p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.806925/full |
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| author | Eleni Pagkopoulou Stergios Soulaidopoulos Eva Triantafyllidou Afrodite Malliari George D. Kitas George D. Kitas Alexandros Garyfallos Theodoros Dimitroulas |
| author_facet | Eleni Pagkopoulou Stergios Soulaidopoulos Eva Triantafyllidou Afrodite Malliari George D. Kitas George D. Kitas Alexandros Garyfallos Theodoros Dimitroulas |
| author_sort | Eleni Pagkopoulou |
| collection | DOAJ |
| description | Objective: The key element in the pathogenesis of systemic sclerosis (SSc) is microcirculatory changes in several vascular beds. Uric acid is associated with endothelial dysfunction and therefore, microvascular damage. The aim of this study was to examine the association between uric acid (UA) and peripheral microvascular involvement in patients with SSc.Methods: We included consecutive, consenting patients with SSc. Serum UA, urea and creatinine were measured, and glomerular filtration rate (GFR) was calculated with CKD-EPI. All participants underwent nailfold video-capillaroscopy (NVC) to evaluate the microcirculation.Results: A total of 64 patients (95.3% women) were included in the study. UA levels were significantly associated with the number of avascular areas (r = 0.290; p = 0.020), whereas no correlation was shown for the GFR (r = −0.065; p = 0.609). A significant trend of UA in the three capillaroscopic patterns was shown (3.90 ± 1.52 vs. 4.15 ± 0.98 vs. 5.38 ± 2.26; for early, active, and late patterns respectively, p = 0.028). Multivariate analysis showed that male gender (β = 3.049; 95% CI = 0.997–5.101) and UA (β = 0.352; 95% CI = 0.117–0.588) were independently associated with the number of avascular areas.Conclusion: These data suggest that UA levels are significantly associated with the capillaroscopic patterns, reflecting a progressive microvasculopathy. |
| first_indexed | 2024-12-21T23:53:35Z |
| format | Article |
| id | doaj.art-ab25e694e1e24066bd4b5381727ff7f1 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-21T23:53:35Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ab25e694e1e24066bd4b5381727ff7f12022-12-21T18:45:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-12-01810.3389/fmed.2021.806925806925Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic SclerosisEleni Pagkopoulou0Stergios Soulaidopoulos1Eva Triantafyllidou2Afrodite Malliari3George D. Kitas4George D. Kitas5Alexandros Garyfallos6Theodoros Dimitroulas7Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceFirst Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, GreeceFourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceInternational Hellenic University, Thessaloniki, GreeceDepartment of Rheumatology, Dudley Group of Hospitals, NS Foundation Trust, Dudley, United KingdomArthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United KingdomFourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceFourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceObjective: The key element in the pathogenesis of systemic sclerosis (SSc) is microcirculatory changes in several vascular beds. Uric acid is associated with endothelial dysfunction and therefore, microvascular damage. The aim of this study was to examine the association between uric acid (UA) and peripheral microvascular involvement in patients with SSc.Methods: We included consecutive, consenting patients with SSc. Serum UA, urea and creatinine were measured, and glomerular filtration rate (GFR) was calculated with CKD-EPI. All participants underwent nailfold video-capillaroscopy (NVC) to evaluate the microcirculation.Results: A total of 64 patients (95.3% women) were included in the study. UA levels were significantly associated with the number of avascular areas (r = 0.290; p = 0.020), whereas no correlation was shown for the GFR (r = −0.065; p = 0.609). A significant trend of UA in the three capillaroscopic patterns was shown (3.90 ± 1.52 vs. 4.15 ± 0.98 vs. 5.38 ± 2.26; for early, active, and late patterns respectively, p = 0.028). Multivariate analysis showed that male gender (β = 3.049; 95% CI = 0.997–5.101) and UA (β = 0.352; 95% CI = 0.117–0.588) were independently associated with the number of avascular areas.Conclusion: These data suggest that UA levels are significantly associated with the capillaroscopic patterns, reflecting a progressive microvasculopathy.https://www.frontiersin.org/articles/10.3389/fmed.2021.806925/fulluric acidnailfold video-capillaroscopymicrovasculopathysystemic sclerosiscardiovascular |
| spellingShingle | Eleni Pagkopoulou Stergios Soulaidopoulos Eva Triantafyllidou Afrodite Malliari George D. Kitas George D. Kitas Alexandros Garyfallos Theodoros Dimitroulas Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis Frontiers in Medicine uric acid nailfold video-capillaroscopy microvasculopathy systemic sclerosis cardiovascular |
| title | Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis |
| title_full | Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis |
| title_fullStr | Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis |
| title_full_unstemmed | Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis |
| title_short | Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis |
| title_sort | association between uric acid and worsening peripheral microangiopathy in systemic sclerosis |
| topic | uric acid nailfold video-capillaroscopy microvasculopathy systemic sclerosis cardiovascular |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.806925/full |
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