The early-life exposome: Description and patterns in six European countries
Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases.Here, we aimed to describe the early-life exposome. Specifically, we focused on the c...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018316295 |
| _version_ | 1818197932388646912 |
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| author | Ibon Tamayo-Uria Léa Maitre Cathrine Thomsen Mark J. Nieuwenhuijsen Leda Chatzi Valérie Siroux Gunn Marit Aasvang Lydiane Agier Sandra Andrusaityte Maribel Casas Montserrat de Castro Audrius Dedele Line S. Haug Barbara Heude Regina Grazuleviciene Kristine B. Gutzkow Norun H. Krog Dan Mason Rosemary R.C. McEachan Helle M. Meltzer Inga Petraviciene Oliver Robinson Theano Roumeliotaki Amrit K. Sakhi Jose Urquiza Marina Vafeiadi Dagmar Waiblinger Charline Warembourg John Wright Rémy Slama Martine Vrijheid Xavier Basagaña |
| author_facet | Ibon Tamayo-Uria Léa Maitre Cathrine Thomsen Mark J. Nieuwenhuijsen Leda Chatzi Valérie Siroux Gunn Marit Aasvang Lydiane Agier Sandra Andrusaityte Maribel Casas Montserrat de Castro Audrius Dedele Line S. Haug Barbara Heude Regina Grazuleviciene Kristine B. Gutzkow Norun H. Krog Dan Mason Rosemary R.C. McEachan Helle M. Meltzer Inga Petraviciene Oliver Robinson Theano Roumeliotaki Amrit K. Sakhi Jose Urquiza Marina Vafeiadi Dagmar Waiblinger Charline Warembourg John Wright Rémy Slama Martine Vrijheid Xavier Basagaña |
| author_sort | Ibon Tamayo-Uria |
| collection | DOAJ |
| description | Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases.Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6–11 years in 6 European birth cohorts.Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures.In conclusion, the early life exposome was high dimensional, meaning that it cannot easily be measured by or reduced to fewer components. Correlations between exposures from different exposure groups were much lower than within exposure groups, which have important implications for co-exposure confounding in multiple exposure studies. Also, we observed the early life exposome to be variable over time and to vary by cohort, so measurements at one time point or one place will not capture its complexities. Keywords: Exposome, Environmental exposures, Early life, Pregnancy, Children |
| first_indexed | 2024-12-12T01:57:50Z |
| format | Article |
| id | doaj.art-ab26871a31cc41fa81c3580ffb43a8f4 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-12T01:57:50Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-ab26871a31cc41fa81c3580ffb43a8f42022-12-22T00:42:18ZengElsevierEnvironment International0160-41202019-02-01123189200The early-life exposome: Description and patterns in six European countriesIbon Tamayo-Uria0Léa Maitre1Cathrine Thomsen2Mark J. Nieuwenhuijsen3Leda Chatzi4Valérie Siroux5Gunn Marit Aasvang6Lydiane Agier7Sandra Andrusaityte8Maribel Casas9Montserrat de Castro10Audrius Dedele11Line S. Haug12Barbara Heude13Regina Grazuleviciene14Kristine B. Gutzkow15Norun H. Krog16Dan Mason17Rosemary R.C. McEachan18Helle M. Meltzer19Inga Petraviciene20Oliver Robinson21Theano Roumeliotaki22Amrit K. Sakhi23Jose Urquiza24Marina Vafeiadi25Dagmar Waiblinger26Charline Warembourg27John Wright28Rémy Slama29Martine Vrijheid30Xavier Basagaña31ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Statistics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USAISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainNorwegian Institute of Public Health, Oslo, NorwayISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USATeam of Environmental Epidemiology, IAB, Institute for Advanced Biosciences, Inserm, CNRS, CHU-Grenoble-Alpes, University Grenoble-Alpes, Grenoble, FranceNorwegian Institute of Public Health, Oslo, NorwayTeam of Environmental Epidemiology, IAB, Institute for Advanced Biosciences, Inserm, CNRS, CHU-Grenoble-Alpes, University Grenoble-Alpes, Grenoble, FranceDepartment of Environmental Sciences, Vytautas Magnus University, Kaunas, LithuaniaISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainDepartment of Environmental Sciences, Vytautas Magnus University, Kaunas, LithuaniaNorwegian Institute of Public Health, Oslo, NorwayINSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team ‘Early Origin of the child's Health and Development’ (ORCHAD), Villejuif, France; Paris Descartes University, Paris, FranceDepartment of Environmental Sciences, Vytautas Magnus University, Kaunas, LithuaniaNorwegian Institute of Public Health, Oslo, NorwayNorwegian Institute of Public Health, Oslo, NorwayBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKNorwegian Institute of Public Health, Oslo, NorwayDepartment of Environmental Sciences, Vytautas Magnus University, Kaunas, LithuaniaISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UKDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, GreeceNorwegian Institute of Public Health, Oslo, NorwayISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, GreeceBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKTeam of Environmental Epidemiology, IAB, Institute for Advanced Biosciences, Inserm, CNRS, CHU-Grenoble-Alpes, University Grenoble-Alpes, Grenoble, FranceISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), SpainISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Corresponding author at: ISGlobal, Institute for Global Health, C/Doctor Aiguader 88, 08003 Barcelona, Spain.Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases.Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6–11 years in 6 European birth cohorts.Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures.In conclusion, the early life exposome was high dimensional, meaning that it cannot easily be measured by or reduced to fewer components. Correlations between exposures from different exposure groups were much lower than within exposure groups, which have important implications for co-exposure confounding in multiple exposure studies. Also, we observed the early life exposome to be variable over time and to vary by cohort, so measurements at one time point or one place will not capture its complexities. Keywords: Exposome, Environmental exposures, Early life, Pregnancy, Childrenhttp://www.sciencedirect.com/science/article/pii/S0160412018316295 |
| spellingShingle | Ibon Tamayo-Uria Léa Maitre Cathrine Thomsen Mark J. Nieuwenhuijsen Leda Chatzi Valérie Siroux Gunn Marit Aasvang Lydiane Agier Sandra Andrusaityte Maribel Casas Montserrat de Castro Audrius Dedele Line S. Haug Barbara Heude Regina Grazuleviciene Kristine B. Gutzkow Norun H. Krog Dan Mason Rosemary R.C. McEachan Helle M. Meltzer Inga Petraviciene Oliver Robinson Theano Roumeliotaki Amrit K. Sakhi Jose Urquiza Marina Vafeiadi Dagmar Waiblinger Charline Warembourg John Wright Rémy Slama Martine Vrijheid Xavier Basagaña The early-life exposome: Description and patterns in six European countries Environment International |
| title | The early-life exposome: Description and patterns in six European countries |
| title_full | The early-life exposome: Description and patterns in six European countries |
| title_fullStr | The early-life exposome: Description and patterns in six European countries |
| title_full_unstemmed | The early-life exposome: Description and patterns in six European countries |
| title_short | The early-life exposome: Description and patterns in six European countries |
| title_sort | early life exposome description and patterns in six european countries |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018316295 |
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