Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy
Context: Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL). AIMS: The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester. Materials and Methods: A total of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=4;spage=224;epage=229;aulast=Mekaj |
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| author | Ymer Mekaj Shefqet Lulaj Fetie Daci Naser Rafuna Ermira Miftari Hakif Hoxha Xhemile Sllamniku Agon Mekaj |
| author_facet | Ymer Mekaj Shefqet Lulaj Fetie Daci Naser Rafuna Ermira Miftari Hakif Hoxha Xhemile Sllamniku Agon Mekaj |
| author_sort | Ymer Mekaj |
| collection | DOAJ |
| description | Context: Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL). AIMS: The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester.
Materials and Methods: A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method. Results: In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%). Conclusion: Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature. |
| first_indexed | 2024-12-11T19:44:17Z |
| format | Article |
| id | doaj.art-ab297082e1184ba99ee5b0eaae60ed10 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-11T19:44:17Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-ab297082e1184ba99ee5b0eaae60ed102022-12-22T00:52:56ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662015-01-018422422910.4103/0974-1208.170407Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancyYmer MekajShefqet LulajFetie DaciNaser RafunaErmira MiftariHakif HoxhaXhemile SllamnikuAgon MekajContext: Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL). AIMS: The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester. Materials and Methods: A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method. Results: In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%). Conclusion: Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=4;spage=224;epage=229;aulast=MekajActivated protein C resistanceantithrombin IIIearly pregnancy lossprotein Cprotein Srepeated miscarriagesthrombophilia |
| spellingShingle | Ymer Mekaj Shefqet Lulaj Fetie Daci Naser Rafuna Ermira Miftari Hakif Hoxha Xhemile Sllamniku Agon Mekaj Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy Journal of Human Reproductive Sciences Activated protein C resistance antithrombin III early pregnancy loss protein C protein S repeated miscarriages thrombophilia |
| title | Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| title_full | Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| title_fullStr | Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| title_full_unstemmed | Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| title_short | Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| title_sort | prevalence and role of antithrombin iii protein c and protein s deficiencies and activated protein c resistance in kosovo women with recurrent pregnancy loss during the first trimester of pregnancy |
| topic | Activated protein C resistance antithrombin III early pregnancy loss protein C protein S repeated miscarriages thrombophilia |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=4;spage=224;epage=229;aulast=Mekaj |
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