Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran
Materials and methods: This descriptive study included all hyperthyroid patients. All therapeutic results were recorded and analyzed. Results: In this study, 329 records were studied and 104 patients met the study inclusion criteria. Graves' disease (GD) and toxic adenoma were reported in 94% a...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-12-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-13909-en.html |
| _version_ | 1797944091856601088 |
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| author | Seyyede Faride Langari Adele Bahar Ozra Akha Adeleh Sahebnasagh Zahra Kashi |
| author_facet | Seyyede Faride Langari Adele Bahar Ozra Akha Adeleh Sahebnasagh Zahra Kashi |
| author_sort | Seyyede Faride Langari |
| collection | DOAJ |
| description | Materials and methods: This descriptive study included all hyperthyroid patients. All therapeutic results were recorded and analyzed.
Results: In this study, 329 records were studied and 104 patients met the study inclusion criteria. Graves' disease (GD) and toxic adenoma were reported in 94% and 6%, respectively. Among the patients with GD, 30.5% (21.7-40.3%) did not respond to initial ATD treatment and 20% had recurrent GD despite appropriate initial response. Overall, antithyroid drugs failure occurred in 50.5% (40.45-60.55%) of the patients. Lower age, lower body mass index (BMI), high thyroid weight, and higher baseline thyroid hormone levels were associated with ATD failure (P <0.05). Patients with toxic adenomas and patients who did not respond to ATD or those who experienced relapse of hyperthyroidism received radioactive iodine or underwent surgery. Hypothyroidism occurred in 13.1% of patients with ATD alone, in 66.7% of those with surgery, and in 79.4% of the patients who received radioactive iodine (P= 0.0001).
Conclusion: A significant proportion of hyperthyroid patients experience drug failure. Age, BMI, thyroid weight, and basal levels of thyroid hormones are associated with drug treatment failure. Prevalence of hypothyroidism after treatment with radioactive iodine is higher than the drug treatment alone or surgery groups. |
| first_indexed | 2024-04-10T20:33:08Z |
| format | Article |
| id | doaj.art-ab29eebff0c342d69771987d445df66c |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:33:08Z |
| publishDate | 2019-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-ab29eebff0c342d69771987d445df66c2023-01-25T05:07:08ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792019-12-0129180124128Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of IranSeyyede Faride Langari0Adele Bahar1Ozra Akha2Adeleh Sahebnasagh3Zahra Kashi4 Resident in Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Associate Professor, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Internal Medicine, Clinical Research Development Unit, North Khorasan University of Medical Sciences, Bojnurd, Iran Professor, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Materials and methods: This descriptive study included all hyperthyroid patients. All therapeutic results were recorded and analyzed. Results: In this study, 329 records were studied and 104 patients met the study inclusion criteria. Graves' disease (GD) and toxic adenoma were reported in 94% and 6%, respectively. Among the patients with GD, 30.5% (21.7-40.3%) did not respond to initial ATD treatment and 20% had recurrent GD despite appropriate initial response. Overall, antithyroid drugs failure occurred in 50.5% (40.45-60.55%) of the patients. Lower age, lower body mass index (BMI), high thyroid weight, and higher baseline thyroid hormone levels were associated with ATD failure (P <0.05). Patients with toxic adenomas and patients who did not respond to ATD or those who experienced relapse of hyperthyroidism received radioactive iodine or underwent surgery. Hypothyroidism occurred in 13.1% of patients with ATD alone, in 66.7% of those with surgery, and in 79.4% of the patients who received radioactive iodine (P= 0.0001). Conclusion: A significant proportion of hyperthyroid patients experience drug failure. Age, BMI, thyroid weight, and basal levels of thyroid hormones are associated with drug treatment failure. Prevalence of hypothyroidism after treatment with radioactive iodine is higher than the drug treatment alone or surgery groups.http://jmums.mazums.ac.ir/article-1-13909-en.htmlgravestoxic adenomaantithyroid drugsradioactive iodinethyroidectomyhypothyroidism |
| spellingShingle | Seyyede Faride Langari Adele Bahar Ozra Akha Adeleh Sahebnasagh Zahra Kashi Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran Journal of Mazandaran University of Medical Sciences graves toxic adenoma antithyroid drugs radioactive iodine thyroidectomy hypothyroidism |
| title | Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran |
| title_full | Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran |
| title_fullStr | Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran |
| title_full_unstemmed | Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran |
| title_short | Therapeutic Outcomes of Hyperthyroidism: A Ten-year Investigation in an Endocrine Clinic in North of Iran |
| title_sort | therapeutic outcomes of hyperthyroidism a ten year investigation in an endocrine clinic in north of iran |
| topic | graves toxic adenoma antithyroid drugs radioactive iodine thyroidectomy hypothyroidism |
| url | http://jmums.mazums.ac.ir/article-1-13909-en.html |
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