Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis
Background and objectives. The clinical course of myasthenia gravis (MG) varies and may adversely affect quality of life and limit daily activities. Repetitive nerve stimulation (RNS) can be used to diagnose MG and may predict disease progression. We aim to establish the correlation between RNS and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2023-09-01
|
| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-02.pdf |
| _version_ | 1797354106436714496 |
|---|---|
| author | Pricilla Yani Gunawan Sindy Chai Reza Stevano |
| author_facet | Pricilla Yani Gunawan Sindy Chai Reza Stevano |
| author_sort | Pricilla Yani Gunawan |
| collection | DOAJ |
| description | Background and objectives. The clinical course of myasthenia gravis (MG) varies and may adversely affect quality of life and limit daily activities. Repetitive nerve stimulation (RNS) can be used to diagnose MG and may predict disease progression. We aim to establish the correlation between RNS and pharmacological treatment response. Materials and methods. We conducted a cross-sectional study evaluating the correlation between RNS result and pharmacological treatment response as evaluated using the Myasthenia Gravis-Activities of Daily Living (MG-ADL). Results. RNS positive patients possess greater severity on pre-treatment (9 [5-11] vs. 4 [2-5], p<0.001) and post-treatment (2 [1-4] vs. 1 [0-2], p=0.007) MG-ADL scores. ∆MG-ADL was also significantly greater in RNS positive patients (-6[-7- -3) vs. -2 [-5 - -1], p=0.004). Spearman’s rank-order correlation conducted evaluating the correlation between RNS and ∆MG-ADL demonstrates a significant moderate positive correlation between RNS and ∆MG-ADL (rs=0.495, p<0.001). Conclusions. A moderate significant correlation was found between RNS and pharmacological treatment response. RNS
positive patients are more responsive towards treatment compared to RNS negative patients. Higher fatigability in muscles translates to greater RNS decrements and clinical severity, lending itself to a greater opportunity for improvement following pharmacological. However, this must not be confused with long-term prognosis. |
| first_indexed | 2024-03-08T13:40:29Z |
| format | Article |
| id | doaj.art-ab2a9f38838c4b4e98936642e0d99b7f |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-03-08T13:40:29Z |
| publishDate | 2023-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-ab2a9f38838c4b4e98936642e0d99b7f2024-01-16T10:44:35ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942023-09-0122318619010.37897/RJN.2023.3.2Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravisPricilla Yani Gunawan0Sindy Chai1Reza Stevano2Department of Neurology, Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, Indonesia; Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Banten, Indonesia Department of Neurology, Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, IndonesiaDepartment of Neurology, Siloam Hospitals Lippo Village, Tangerang, Banten, Indonesia Background and objectives. The clinical course of myasthenia gravis (MG) varies and may adversely affect quality of life and limit daily activities. Repetitive nerve stimulation (RNS) can be used to diagnose MG and may predict disease progression. We aim to establish the correlation between RNS and pharmacological treatment response. Materials and methods. We conducted a cross-sectional study evaluating the correlation between RNS result and pharmacological treatment response as evaluated using the Myasthenia Gravis-Activities of Daily Living (MG-ADL). Results. RNS positive patients possess greater severity on pre-treatment (9 [5-11] vs. 4 [2-5], p<0.001) and post-treatment (2 [1-4] vs. 1 [0-2], p=0.007) MG-ADL scores. ∆MG-ADL was also significantly greater in RNS positive patients (-6[-7- -3) vs. -2 [-5 - -1], p=0.004). Spearman’s rank-order correlation conducted evaluating the correlation between RNS and ∆MG-ADL demonstrates a significant moderate positive correlation between RNS and ∆MG-ADL (rs=0.495, p<0.001). Conclusions. A moderate significant correlation was found between RNS and pharmacological treatment response. RNS positive patients are more responsive towards treatment compared to RNS negative patients. Higher fatigability in muscles translates to greater RNS decrements and clinical severity, lending itself to a greater opportunity for improvement following pharmacological. However, this must not be confused with long-term prognosis.https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-02.pdfmyasthenia gravistreatment responserepetitive nerve stimulation |
| spellingShingle | Pricilla Yani Gunawan Sindy Chai Reza Stevano Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis Romanian Journal of Neurology myasthenia gravis treatment response repetitive nerve stimulation |
| title | Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| title_full | Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| title_fullStr | Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| title_full_unstemmed | Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| title_short | Repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| title_sort | repetitive nerve stimulation as a predictor of treatment response in myasthenia gravis |
| topic | myasthenia gravis treatment response repetitive nerve stimulation |
| url | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-02.pdf |
| work_keys_str_mv | AT pricillayanigunawan repetitivenervestimulationasapredictoroftreatmentresponseinmyastheniagravis AT sindychai repetitivenervestimulationasapredictoroftreatmentresponseinmyastheniagravis AT rezastevano repetitivenervestimulationasapredictoroftreatmentresponseinmyastheniagravis |