Effect of pantethine on ovarian tumor progression and choline metabolism

Effect of pantethine on ovarian tumor progression and choline metabolism

Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. New therapeutic strategies evaluated with relevant preclinical models are urgently needed to improve survival rates. Here we have assessed the effect of pantethine on tumor gr...

Full description

Bibliographic Details
Main Authors:	Marie-France Penet, Balaji Krishnamachary, Flonne Wildes, Yelena Mironchik, Delia Mezzanzanica, Franca Podo, Max DE REGGI, Bouchra Gharib, Zaver M Bhujwalla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-11-01
Series:	Frontiers in Oncology
Subjects:	Ascites metastasis ovarian cancer Orthotopic model choline metabolism Pantethine
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00244/full

Similar Items

Ascites Volumes and the Ovarian Cancer Microenvironment
by: Marie-France Penet, et al.
Published: (2018-12-01)

The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
by: Jesus Pacheco-Torres, et al.
Published: (2021-02-01)

Water and Collagen Content Are High in Pancreatic Cancer: Implications for Quantitative Metabolic Imaging
by: Marie-France Penet, et al.
Published: (2021-01-01)

PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation
by: Jesus Pacheco-Torres, et al.
Published: (2021-02-01)

VEGF Overexpression Significantly Increases Nanoparticle-Mediated siRNA Delivery and Target-Gene Downregulation
by: Shanshan Tan, et al.
Published: (2022-06-01)

Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy
by: Zhihang Chen, et al.
Published: (2016-02-01)

Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells
by: Noriko Mori, et al.
Published: (2023-03-01)

PD-L1 near Infrared Photoimmunotherapy of Ovarian Cancer Model
by: Jiefu Jin, et al.
Published: (2022-01-01)

Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling
by: Eibhlin Goggins, et al.
Published: (2023-12-01)

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts
by: Eibhlin Goggins, et al.
Published: (2018-02-01)

Mechanisms of Indomethacin-Induced Alterations in the Choline Phospholipid Metabolism of Breast Cancer Cells
by: Kristine Glunde, et al.
Published: (2006-09-01)

Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
by: Balaji Krishnamachary, et al.
Published: (2012-01-01)

COX-2 in Cancer: Gordian knot or Achilles heel?
by: Ioannis eStasinopoulos, et al.
Published: (2013-03-01)

Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia
by: Jesus Pacheco-Torres, et al.
Published: (2024-03-01)

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
by: Fanni Tóth, et al.
Published: (2021-01-01)

Pilot trial on the efficacy and safety of pantethine in children with pantothenate kinase-associated neurodegeneration: a single-arm, open-label study
by: Xuting Chang, et al.
Published: (2020-09-01)

Exposure of Human Breast Cancer Cells to the Anti-inflammatory Agent Indomethacin Alters Choline Phospholipid Metabolites and Nm23 Expression
by: Kshama Natarajan, et al.
Published: (2002-01-01)

Phototheranostics of Splenic Myeloid-Derived Suppressor Cells and Its Impact on Spleen Metabolism in Tumor-Bearing Mice
by: James D. Barnett, et al.
Published: (2022-07-01)

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors
by: Pierre Danhier, et al.
Published: (2015-12-01)

Pantethine as source for pantothenic acid added as a nutritional substance in food supplements ‐ Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food (ANS)
by: European Food Safety Authority (EFSA)
Published: (2008-11-01)

Biomimetic Nanoparticles Camouflaged in Cancer Cell Membranes and Their Applications in Cancer Theranostics
by: Jiefu Jin, et al.
Published: (2020-01-01)

Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer
by: Elena Mariotto, et al.
Published: (2018-10-01)

Editorial: Exploring Cancer Metabolic Reprogramming through Molecular Imaging
by: Franca Podo, et al.
Published: (2017-04-01)

Choline supplements: An update
by: Urna Kansakar, et al.
Published: (2023-03-01)

Pharmacodynamic Markers for Choline Kinase Down-regulation in Breast Cancer Cells
by: Sridhar Nimmagadda, et al.
Published: (2009-05-01)

Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer
by: Menglin Cheng, et al.
Published: (2017-08-01)

A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer.
by: Elena V Rosca, et al.
Published: (2014-01-01)

Hypoxia Increases Breast Cancer Cell-Induced Lymphatic Endothelial Cell Migration
by: Maria Mikhaylova, et al.
Published: (2008-04-01)

Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport.
by: Samata M Kakkad, et al.
Published: (2013-01-01)

In vivo "MRI phenotyping" reveals changes in extracellular matrix transport and vascularization that mediate VEGF-driven increase in breast cancer metastasis.
by: Arvind P Pathak, et al.
Published: (2013-01-01)

Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease
by: Daniela Zizioli, et al.
Published: (2016-01-01)

Ovarian Cancer Targeted Theranostics
by: Sridhar Nimmagadda, et al.
Published: (2020-01-01)

Effects of choline containing phospholipids on the neurovascular unit: A review
by: Proshanta Roy, et al.
Published: (2022-09-01)

Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome
by: Marissa DiBella, et al.
Published: (2020-10-01)

Changes in plasma and milk choline metabolite concentrations in response to the provision of various rumen-protected choline prototypes in lactating dairy cows
by: Tanya L. France, et al.
Published: (2022-11-01)

Choline Phospholipid Metabolites of Human Vascular Endothelial Cells Altered by Cyclooxygenase Inhibition, Growth Factor Depletion, and Paracrine Factors Secreted by Cancer Cells
by: Noriko Mori, et al.
Published: (2003-04-01)

Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline
by: Noriko Mori, et al.
Published: (2004-10-01)

Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines
by: Pablo García-Molina, et al.
Published: (2022-02-01)

Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology
by: Ramasamy Selvam, et al.
Published: (2018-11-01)

Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors
by: Santiago Schiaffino-Ortega, et al.
Published: (2021-08-01)