Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications
Polymers in which phosphorus is an integral part of the main chain, including polyphosphazenes and polyphosphoesters, have been widely investigated in recent years for their potential in a number of therapeutic applications. Phosphorus, as the central feature of these polymers, endears the chemical...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/7/1716 |
| _version_ | 1797571143825096704 |
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| author | Paul Strasser Ian Teasdale |
| author_facet | Paul Strasser Ian Teasdale |
| author_sort | Paul Strasser |
| collection | DOAJ |
| description | Polymers in which phosphorus is an integral part of the main chain, including polyphosphazenes and polyphosphoesters, have been widely investigated in recent years for their potential in a number of therapeutic applications. Phosphorus, as the central feature of these polymers, endears the chemical functionalization, and in some cases (bio)degradability, to facilitate their use in such therapeutic formulations. Recent advances in the synthetic polymer chemistry have allowed for controlled synthesis methods in order to prepare the complex macromolecular structures required, alongside the control and reproducibility desired for such medical applications. While the main polymer families described herein, polyphosphazenes and polyphosphoesters and their analogues, as well as phosphorus-based dendrimers, have hitherto predominantly been investigated in isolation from one another, this review aims to highlight and bring together some of this research. In doing so, the focus is placed on the essential, and often mutual, design features and structure–property relationships that allow the preparation of such functional materials. The first part of the review details the relevant features of phosphorus-containing polymers in respect to their use in therapeutic applications, while the second part highlights some recent and innovative applications, offering insights into the most state-of-the-art research on phosphorus-based polymers in a therapeutic context. |
| first_indexed | 2024-03-10T20:36:05Z |
| format | Article |
| id | doaj.art-ab2b18d306b04ba2b21548111fa195c4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:36:05Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ab2b18d306b04ba2b21548111fa195c42023-11-19T21:03:48ZengMDPI AGMolecules1420-30492020-04-01257171610.3390/molecules25071716Main-Chain Phosphorus-Containing Polymers for Therapeutic ApplicationsPaul Strasser0Ian Teasdale1Institute of Polymer Chemistry, Johannes Kepler University Linz (JKU), Altenberger Straße 69, A-4040 Linz, AustriaInstitute of Polymer Chemistry, Johannes Kepler University Linz (JKU), Altenberger Straße 69, A-4040 Linz, AustriaPolymers in which phosphorus is an integral part of the main chain, including polyphosphazenes and polyphosphoesters, have been widely investigated in recent years for their potential in a number of therapeutic applications. Phosphorus, as the central feature of these polymers, endears the chemical functionalization, and in some cases (bio)degradability, to facilitate their use in such therapeutic formulations. Recent advances in the synthetic polymer chemistry have allowed for controlled synthesis methods in order to prepare the complex macromolecular structures required, alongside the control and reproducibility desired for such medical applications. While the main polymer families described herein, polyphosphazenes and polyphosphoesters and their analogues, as well as phosphorus-based dendrimers, have hitherto predominantly been investigated in isolation from one another, this review aims to highlight and bring together some of this research. In doing so, the focus is placed on the essential, and often mutual, design features and structure–property relationships that allow the preparation of such functional materials. The first part of the review details the relevant features of phosphorus-containing polymers in respect to their use in therapeutic applications, while the second part highlights some recent and innovative applications, offering insights into the most state-of-the-art research on phosphorus-based polymers in a therapeutic context.https://www.mdpi.com/1420-3049/25/7/1716polyphosphoesterpolyphosphazenepolymer therapeuticsdegradable polymers |
| spellingShingle | Paul Strasser Ian Teasdale Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications Molecules polyphosphoester polyphosphazene polymer therapeutics degradable polymers |
| title | Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications |
| title_full | Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications |
| title_fullStr | Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications |
| title_full_unstemmed | Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications |
| title_short | Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications |
| title_sort | main chain phosphorus containing polymers for therapeutic applications |
| topic | polyphosphoester polyphosphazene polymer therapeutics degradable polymers |
| url | https://www.mdpi.com/1420-3049/25/7/1716 |
| work_keys_str_mv | AT paulstrasser mainchainphosphoruscontainingpolymersfortherapeuticapplications AT ianteasdale mainchainphosphoruscontainingpolymersfortherapeuticapplications |