ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response

ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response

Abstract Background Mitochondrial quality control (MQC) plays a critical role in the progression of tubulointerstitial injury in diabetic kidney disease (DKD). The mitochondrial unfolded protein response (UPRmt), which is an important MQC process, is activated to maintain mitochondrial protein homeo...

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Bibliographic Details
Main Authors: Yifei Liu, Lei Zhang, Shumin Zhang, Jialu Liu, Xiaohui Li, Kexin Yang, Danyi Yang, Yu Liu, Lin Sun, Fuyou Liu, Li Xiao
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Medicine
Subjects:
Diabetic kidney disease
Tubular cell
ATF5
UPRmt
Apoptosis
Oxidative stress
Online Access:https://doi.org/10.1186/s10020-023-00651-4

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