Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study
Abstract Background Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish b...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08353-2 |
| _version_ | 1797811910477873152 |
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| author | Ryo Yamashita Yusuke Izumi Koji Nakada Jun Hiramoto |
| author_facet | Ryo Yamashita Yusuke Izumi Koji Nakada Jun Hiramoto |
| author_sort | Ryo Yamashita |
| collection | DOAJ |
| description | Abstract Background Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish between pyelonephritis and nonpyelonephritis. Methods A cross-sectional study of patients with suspected pyelonephritis was conducted. Urinary presepsin at admission was compared between the pyelonephritis and nonpyelonephritis groups using the Mann–Whitney test. The predictive accuracy of urinary presepsin for diagnosing pyelonephritis was evaluated by the area under the receiver operating characteristics (ROC) analysis curve. Results A total of 35 eligible participants were included in the pyelonephritis group and 25 in the nonpyelonephritis group. The median urinary presepsin level was 2232.0 (interquartile range [IQR], 1029.0–3907.0) pg/mL in the pyelonephritis group and 1348.0 (IQR, 614.5–2304.8) pg/mL in the nonpyelonephritis group. Urinary presepsin concentrations were significantly higher in the pyelonephritis group than in the nonpyelonephritis group (P = 0.023). ROC analysis of urinary presepsin revealed a cutoff value of 3650 pg/mL to distinguish between the pyelonephritis and nonpyelonephritis groups. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio for the diagnosis of pyelonephritis were 0.40 (95% confidence interval [CI], 0.24–0.58), 0.96 (95% CI, 0.79–1.00), 0.93 (95% CI, 0.68–1.00), 0.52 (95% CI, 0.37–0.68), 9.60 (95% CI, 1.35–68.23), and 0.62 (95% CI, 0.47–0.83), respectively. Conclusions The measurement of urinary presepsin is useful in differentiating pyelonephritis from other diseases. |
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| format | Article |
| id | doaj.art-ab2d19dccae84531b93aca3f2fb9fc14 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-13T07:30:47Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ab2d19dccae84531b93aca3f2fb9fc142023-06-04T11:07:38ZengBMCBMC Infectious Diseases1471-23342023-05-012311610.1186/s12879-023-08353-2Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional studyRyo Yamashita0Yusuke Izumi1Koji Nakada2Jun Hiramoto3Department of General Medicine, The Jikei University School of Medicine, Daisan HospitalDepartment of General Medicine, The Jikei University School of Medicine, Daisan HospitalDepartment of Laboratory Medicine, The Jikei University School of Medicine, Daisan HospitalDepartment of General Medicine, The Jikei University School of Medicine, Daisan HospitalAbstract Background Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish between pyelonephritis and nonpyelonephritis. Methods A cross-sectional study of patients with suspected pyelonephritis was conducted. Urinary presepsin at admission was compared between the pyelonephritis and nonpyelonephritis groups using the Mann–Whitney test. The predictive accuracy of urinary presepsin for diagnosing pyelonephritis was evaluated by the area under the receiver operating characteristics (ROC) analysis curve. Results A total of 35 eligible participants were included in the pyelonephritis group and 25 in the nonpyelonephritis group. The median urinary presepsin level was 2232.0 (interquartile range [IQR], 1029.0–3907.0) pg/mL in the pyelonephritis group and 1348.0 (IQR, 614.5–2304.8) pg/mL in the nonpyelonephritis group. Urinary presepsin concentrations were significantly higher in the pyelonephritis group than in the nonpyelonephritis group (P = 0.023). ROC analysis of urinary presepsin revealed a cutoff value of 3650 pg/mL to distinguish between the pyelonephritis and nonpyelonephritis groups. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio for the diagnosis of pyelonephritis were 0.40 (95% confidence interval [CI], 0.24–0.58), 0.96 (95% CI, 0.79–1.00), 0.93 (95% CI, 0.68–1.00), 0.52 (95% CI, 0.37–0.68), 9.60 (95% CI, 1.35–68.23), and 0.62 (95% CI, 0.47–0.83), respectively. Conclusions The measurement of urinary presepsin is useful in differentiating pyelonephritis from other diseases.https://doi.org/10.1186/s12879-023-08353-2PresepsinPyelonephritisPyuriaReceiver operating characteristics |
| spellingShingle | Ryo Yamashita Yusuke Izumi Koji Nakada Jun Hiramoto Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study BMC Infectious Diseases Presepsin Pyelonephritis Pyuria Receiver operating characteristics |
| title | Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study |
| title_full | Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study |
| title_fullStr | Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study |
| title_full_unstemmed | Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study |
| title_short | Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study |
| title_sort | utility of urinary presepsin in the diagnosis of pyelonephritis a cross sectional study |
| topic | Presepsin Pyelonephritis Pyuria Receiver operating characteristics |
| url | https://doi.org/10.1186/s12879-023-08353-2 |
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