Past, Present, and a Glance into the Future of Multiple Myeloma Treatment
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/3/415 |
| _version_ | 1797609590472310784 |
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| author | Weam Othman Elbezanti Kishore B. Challagundla Subash C. Jonnalagadda Tulin Budak-Alpdogan Manoj K. Pandey |
| author_facet | Weam Othman Elbezanti Kishore B. Challagundla Subash C. Jonnalagadda Tulin Budak-Alpdogan Manoj K. Pandey |
| author_sort | Weam Othman Elbezanti |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments. |
| first_indexed | 2024-03-11T06:03:29Z |
| format | Article |
| id | doaj.art-ab2e1b0464064d68991d012df6bd5c4a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T06:03:29Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ab2e1b0464064d68991d012df6bd5c4a2023-11-17T13:12:29ZengMDPI AGPharmaceuticals1424-82472023-03-0116341510.3390/ph16030415Past, Present, and a Glance into the Future of Multiple Myeloma TreatmentWeam Othman Elbezanti0Kishore B. Challagundla1Subash C. Jonnalagadda2Tulin Budak-Alpdogan3Manoj K. Pandey4Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401S Broadway, Camden, NJ 08103, USADepartment of Biochemistry and Molecular Biology, The Fred and Pamela Buffett Cancer Center, The Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USADepartment of Hematology, MD Anderson Cancer Center at Cooper, Cooper Health System, Camden, NJ 08103, USADepartment of Biomedical Sciences, Cooper Medical School of Rowan University, 401S Broadway, Camden, NJ 08103, USAMultiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.https://www.mdpi.com/1424-8247/16/3/415multiple myelomaB-cell malignancybone marrow microenvironmentdrug resistanceproteasome inhibitorsimmunotherapies |
| spellingShingle | Weam Othman Elbezanti Kishore B. Challagundla Subash C. Jonnalagadda Tulin Budak-Alpdogan Manoj K. Pandey Past, Present, and a Glance into the Future of Multiple Myeloma Treatment Pharmaceuticals multiple myeloma B-cell malignancy bone marrow microenvironment drug resistance proteasome inhibitors immunotherapies |
| title | Past, Present, and a Glance into the Future of Multiple Myeloma Treatment |
| title_full | Past, Present, and a Glance into the Future of Multiple Myeloma Treatment |
| title_fullStr | Past, Present, and a Glance into the Future of Multiple Myeloma Treatment |
| title_full_unstemmed | Past, Present, and a Glance into the Future of Multiple Myeloma Treatment |
| title_short | Past, Present, and a Glance into the Future of Multiple Myeloma Treatment |
| title_sort | past present and a glance into the future of multiple myeloma treatment |
| topic | multiple myeloma B-cell malignancy bone marrow microenvironment drug resistance proteasome inhibitors immunotherapies |
| url | https://www.mdpi.com/1424-8247/16/3/415 |
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