A mechanistic model of the organization of cell shapes in epithelial tissues
The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our study, we explore a mechanistic model of cellular organizati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Soft Matter |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frsfm.2023.1214159/full |
| _version_ | 1827162217594748928 |
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| author | Kanaya Malakar Rafael I. Rubenstein Dapeng Bi Bulbul Chakraborty |
| author_facet | Kanaya Malakar Rafael I. Rubenstein Dapeng Bi Bulbul Chakraborty |
| author_sort | Kanaya Malakar |
| collection | DOAJ |
| description | The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our study, we explore a mechanistic model of cellular organization that represents cells as force dipoles that interact with each other via the tissue, which we model as an elastic medium. By conducting numerical simulations using this model, we are able to observe organizational features that are consistent with those obtained from vertex model simulations. This approach provides valuable insights into the underlying mechanisms that govern cellular organization within tissues, which can help us better understand the processes involved in development and disease. |
| first_indexed | 2024-03-11T20:54:08Z |
| format | Article |
| id | doaj.art-ab2eabf54280406e924cf810e4027366 |
| institution | Directory Open Access Journal |
| issn | 2813-0499 |
| language | English |
| last_indexed | 2025-03-21T00:41:18Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Soft Matter |
| spelling | doaj.art-ab2eabf54280406e924cf810e40273662024-08-03T06:12:41ZengFrontiers Media S.A.Frontiers in Soft Matter2813-04992023-09-01310.3389/frsfm.2023.12141591214159A mechanistic model of the organization of cell shapes in epithelial tissuesKanaya Malakar0Rafael I. Rubenstein1Dapeng Bi2Bulbul Chakraborty3Martin A. Fisher School of Physics, Brandeis University, Waltham, MA, United StatesMartin A. Fisher School of Physics, Brandeis University, Waltham, MA, United StatesDepartment of Physics, Northeastern University, Boston, MA, United StatesMartin A. Fisher School of Physics, Brandeis University, Waltham, MA, United StatesThe organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our study, we explore a mechanistic model of cellular organization that represents cells as force dipoles that interact with each other via the tissue, which we model as an elastic medium. By conducting numerical simulations using this model, we are able to observe organizational features that are consistent with those obtained from vertex model simulations. This approach provides valuable insights into the underlying mechanisms that govern cellular organization within tissues, which can help us better understand the processes involved in development and disease.https://www.frontiersin.org/articles/10.3389/frsfm.2023.1214159/fulltissueelasticityorganizationMonte Carloenergy landscape |
| spellingShingle | Kanaya Malakar Rafael I. Rubenstein Dapeng Bi Bulbul Chakraborty A mechanistic model of the organization of cell shapes in epithelial tissues Frontiers in Soft Matter tissue elasticity organization Monte Carlo energy landscape |
| title | A mechanistic model of the organization of cell shapes in epithelial tissues |
| title_full | A mechanistic model of the organization of cell shapes in epithelial tissues |
| title_fullStr | A mechanistic model of the organization of cell shapes in epithelial tissues |
| title_full_unstemmed | A mechanistic model of the organization of cell shapes in epithelial tissues |
| title_short | A mechanistic model of the organization of cell shapes in epithelial tissues |
| title_sort | mechanistic model of the organization of cell shapes in epithelial tissues |
| topic | tissue elasticity organization Monte Carlo energy landscape |
| url | https://www.frontiersin.org/articles/10.3389/frsfm.2023.1214159/full |
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