Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays

Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays

Abstract Background Activated coagulation factor XIa (FXIa) is an impurity and primary source of procoagulant activity in thrombosis‐implicated immune globulin (IG) products. Several assays, of varying quality and precision are used to assess FXIa‐like procoagulant activity in units relevant to thei...

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Bibliographic Details
Main Authors: Yideng Liang, Joseph W. Jackson, Samuel A. Woodle, Stepan S. Surov, Leonid A. Parunov, Dorothy E. Scott, Mark Weinstein, Timothy K. Lee, Mikhail V. Ovanesov
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
blood coagulation tests
calibration
coagulation factor XIa
immune globulin
thrombin
Online Access:https://doi.org/10.1002/rth2.12467

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