Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study.
<h4>Objective</h4>Measures of Doppler blood flow velocity profiles are an integral part of monitoring fetal well-being during pregnancy. These examinations are performed at different times of the day and at different maternal meal states. In uncomplicated pregnancies, we assessed the eff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272062 |
| _version_ | 1817999573458616320 |
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| author | Saba Muneer Zahid Gun Lisbet Opheim Tore Henriksen Trond Melbye Michelsen Guttorm Haugen |
| author_facet | Saba Muneer Zahid Gun Lisbet Opheim Tore Henriksen Trond Melbye Michelsen Guttorm Haugen |
| author_sort | Saba Muneer Zahid |
| collection | DOAJ |
| description | <h4>Objective</h4>Measures of Doppler blood flow velocity profiles are an integral part of monitoring fetal well-being during pregnancy. These examinations are performed at different times of the day and at different maternal meal states. In uncomplicated pregnancies, we assessed the effect of a standardized maternal meal on middle cerebral artery (MCA) and umbilical artery (UA) Doppler blood flow velocity pulsatility indices (PIs) and MCA peak systolic velocity (PSV).<h4>Methods</h4>In this prospective single-blinded crossover study 25 healthy women were examined at 36 weeks of pregnancy. The first examination was performed in the morning following overnight fast, and repeated after extended fast (state A), and after a standard breakfast meal (state B).<h4>Results</h4>Irrespective of maternal prandial status, the MCA-PI values were lower in the 2nd compared to the 1st examination (-0.187; p = 0.071, and -0.113; p = 0.099, state A and B, respectively). Compared to the values in the 1st examination, the UA-PI values, were higher after extended fast (0.014; p = 0.436), and lower post-prandially (-0.036; p = 0.070). The difference (state B minus state A) between the meal states were not significant (0.074; p = 0.487 and -0.050; p = 0.058, for MCA-PI and UA-PI, respectively). Adjusting for the possible influence of fetal heart rate on MCA-PI and UA-PI, the differences between meal states remained non-significant (p = 0.179, p = 0.064, respectively). The MCA-PSV values increased after the meal (6.812; p = 0.035), whereas no increase was observed following extended fast (0.140; p = 0.951). The difference in MCA-PSV values between the two meal states was not significant (6.672; p = 0.055).<h4>Conclusion</h4>Our results demonstrate possible diurnal variations in MCA-PI and UA-PI, with and without adjustment for fetal heart rate, that seem to be unaffected by maternal meal intake in healthy pregnancies. |
| first_indexed | 2024-04-14T03:10:44Z |
| format | Article |
| id | doaj.art-ab2f5c397de543de994b22b0808dc7dc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T03:10:44Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-ab2f5c397de543de994b22b0808dc7dc2022-12-22T02:15:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027206210.1371/journal.pone.0272062Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study.Saba Muneer ZahidGun Lisbet OpheimTore HenriksenTrond Melbye MichelsenGuttorm Haugen<h4>Objective</h4>Measures of Doppler blood flow velocity profiles are an integral part of monitoring fetal well-being during pregnancy. These examinations are performed at different times of the day and at different maternal meal states. In uncomplicated pregnancies, we assessed the effect of a standardized maternal meal on middle cerebral artery (MCA) and umbilical artery (UA) Doppler blood flow velocity pulsatility indices (PIs) and MCA peak systolic velocity (PSV).<h4>Methods</h4>In this prospective single-blinded crossover study 25 healthy women were examined at 36 weeks of pregnancy. The first examination was performed in the morning following overnight fast, and repeated after extended fast (state A), and after a standard breakfast meal (state B).<h4>Results</h4>Irrespective of maternal prandial status, the MCA-PI values were lower in the 2nd compared to the 1st examination (-0.187; p = 0.071, and -0.113; p = 0.099, state A and B, respectively). Compared to the values in the 1st examination, the UA-PI values, were higher after extended fast (0.014; p = 0.436), and lower post-prandially (-0.036; p = 0.070). The difference (state B minus state A) between the meal states were not significant (0.074; p = 0.487 and -0.050; p = 0.058, for MCA-PI and UA-PI, respectively). Adjusting for the possible influence of fetal heart rate on MCA-PI and UA-PI, the differences between meal states remained non-significant (p = 0.179, p = 0.064, respectively). The MCA-PSV values increased after the meal (6.812; p = 0.035), whereas no increase was observed following extended fast (0.140; p = 0.951). The difference in MCA-PSV values between the two meal states was not significant (6.672; p = 0.055).<h4>Conclusion</h4>Our results demonstrate possible diurnal variations in MCA-PI and UA-PI, with and without adjustment for fetal heart rate, that seem to be unaffected by maternal meal intake in healthy pregnancies.https://doi.org/10.1371/journal.pone.0272062 |
| spellingShingle | Saba Muneer Zahid Gun Lisbet Opheim Tore Henriksen Trond Melbye Michelsen Guttorm Haugen Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. PLoS ONE |
| title | Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. |
| title_full | Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. |
| title_fullStr | Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. |
| title_full_unstemmed | Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. |
| title_short | Effect of a standardized maternal meal on fetal middle cerebral artery Doppler indices: A single-blinded crossover study. |
| title_sort | effect of a standardized maternal meal on fetal middle cerebral artery doppler indices a single blinded crossover study |
| url | https://doi.org/10.1371/journal.pone.0272062 |
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