Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan
Abstract Direct endothelial injury by viruses and dysregulation of clotting mechanisms due to cytokine storm are the major precipitating factors of mortality in COVID-19; both are attributed to a fundamental dysregulation of the immune system. While immune dysregulation can be attributed to several...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-10-01
|
| Series: | Thrombosis Journal |
| Online Access: | http://link.springer.com/article/10.1186/s12959-020-00239-6 |
| _version_ | 1811293543470202880 |
|---|---|
| author | Nobunao Ikewaki Kosagi-Sharaf Rao Armando Durant Archibold Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Shojiro Katoh Samuel J. K. Abraham |
| author_facet | Nobunao Ikewaki Kosagi-Sharaf Rao Armando Durant Archibold Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Shojiro Katoh Samuel J. K. Abraham |
| author_sort | Nobunao Ikewaki |
| collection | DOAJ |
| description | Abstract Direct endothelial injury by viruses and dysregulation of clotting mechanisms due to cytokine storm are the major precipitating factors of mortality in COVID-19; both are attributed to a fundamental dysregulation of the immune system. While immune dysregulation can be attributed to several factors, the risk of associated thrombogenic disruption varies across individuals. This variation depends on several factors, such as comorbidities, including diabetes, hypertension, and cardiovascular diseases. When considering ethnic variations, the vulnerability of Caucasians, African Americans and Hispanics needs to be addressed before arriving at strategies to handle thromboembolic complications, which have been identified in recent reports as the leading causes of mortality in COVID-19. Although evaluation of D-dimer and prothrombin during admission is considered to predict prognosis and mortality, there are no preventive or prophylactic strategies before hospital admission. Herein, we present our perspectives on the effect of regular supplementation with the biological response modifier beta glucan based on its relevance to immune modulation. This effect is of paramount importance in decreasing the development of severe COVID-19 and reducing mortality against the background of coagulopathy, especially in vulnerable populations. |
| first_indexed | 2024-04-13T05:02:57Z |
| format | Article |
| id | doaj.art-ab30bb5b0f5c47509388dbfdf1431904 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-13T05:02:57Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-ab30bb5b0f5c47509388dbfdf14319042022-12-22T03:01:16ZengBMCThrombosis Journal1477-95602020-10-011811810.1186/s12959-020-00239-6Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier GlucanNobunao Ikewaki0Kosagi-Sharaf Rao1Armando Durant Archibold2Masaru Iwasaki3Rajappa Senthilkumar4Senthilkumar Preethy5Shojiro Katoh6Samuel J. K. Abraham7Department of Medical Life Science, Kyushu University of Health and WelfareInstituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of KnowledgeInstituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of KnowledgeII Department of Surgery & Centre for Advancing Clinical Research (CACR), Yamanashi University- School of MedicineThe Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM)The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM)Edogawa Evolutionary Laboratory of Science (EELS), Edogawa HospitalII Department of Surgery & Centre for Advancing Clinical Research (CACR), Yamanashi University- School of MedicineAbstract Direct endothelial injury by viruses and dysregulation of clotting mechanisms due to cytokine storm are the major precipitating factors of mortality in COVID-19; both are attributed to a fundamental dysregulation of the immune system. While immune dysregulation can be attributed to several factors, the risk of associated thrombogenic disruption varies across individuals. This variation depends on several factors, such as comorbidities, including diabetes, hypertension, and cardiovascular diseases. When considering ethnic variations, the vulnerability of Caucasians, African Americans and Hispanics needs to be addressed before arriving at strategies to handle thromboembolic complications, which have been identified in recent reports as the leading causes of mortality in COVID-19. Although evaluation of D-dimer and prothrombin during admission is considered to predict prognosis and mortality, there are no preventive or prophylactic strategies before hospital admission. Herein, we present our perspectives on the effect of regular supplementation with the biological response modifier beta glucan based on its relevance to immune modulation. This effect is of paramount importance in decreasing the development of severe COVID-19 and reducing mortality against the background of coagulopathy, especially in vulnerable populations.http://link.springer.com/article/10.1186/s12959-020-00239-6 |
| spellingShingle | Nobunao Ikewaki Kosagi-Sharaf Rao Armando Durant Archibold Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Shojiro Katoh Samuel J. K. Abraham Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan Thrombosis Journal |
| title | Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan |
| title_full | Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan |
| title_fullStr | Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan |
| title_full_unstemmed | Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan |
| title_short | Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan |
| title_sort | coagulopathy associated with covid 19 perspectives preventive strategies using a biological response modifier glucan |
| url | http://link.springer.com/article/10.1186/s12959-020-00239-6 |
| work_keys_str_mv | AT nobunaoikewaki coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT kosagisharafrao coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT armandodurantarchibold coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT masaruiwasaki coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT rajappasenthilkumar coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT senthilkumarpreethy coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT shojirokatoh coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan AT samueljkabraham coagulopathyassociatedwithcovid19perspectivespreventivestrategiesusingabiologicalresponsemodifierglucan |