A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors.
We propose a modification of the well-known Armitage trend test to address the problems associated with hidden population structure and hidden relatedness in genome-wide case-control association studies.The new test adopts beneficial traits from three existing testing strategies: the principal compo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-06-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2688076?pdf=render |