Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted

Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted

In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds. The reaction conditions considered ideal were determined fro...

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Bibliographic Details
Main Authors: Regina Westphal, Eclair Venturini Filho, Laiza Bruzadelle Loureiro, Cláudio Francisco Tormena, Claudia Pessoa, Celina de Jesus Guimarães, Mariana Palmeira Manso, Rodolfo Goetze Fiorot, Vinicius Rangel Campos, Jackson Antônio Lamounier Camargos Resende, Fabrizio Medici, Sandro José Greco
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
spiro compound
domino reaction
multicomponent reaction
ionic liquid
anticancer activity
Online Access:https://www.mdpi.com/1420-3049/27/22/8051

Internet

https://www.mdpi.com/1420-3049/27/22/8051

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