A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterised by cognitive impairment, and amyloid-β plaques and neurofibrillary tau tangles at neuropathology. Capsaicin is a spicy-tasting compound found in chili peppers, with anti-inflammatory, antioxidant, and possible neuropr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10176 |
| _version_ | 1797594296223793152 |
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| author | Deborah Inyang Tasneem Saumtally Chinelo Nonyerem Nnadi Sharmila Devi Po-Wah So |
| author_facet | Deborah Inyang Tasneem Saumtally Chinelo Nonyerem Nnadi Sharmila Devi Po-Wah So |
| author_sort | Deborah Inyang |
| collection | DOAJ |
| description | Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterised by cognitive impairment, and amyloid-β plaques and neurofibrillary tau tangles at neuropathology. Capsaicin is a spicy-tasting compound found in chili peppers, with anti-inflammatory, antioxidant, and possible neuroprotective properties. Capsaicin intake has been associated with greater cognitive function in humans, and attenuating aberrant tau hyperphosphorylation in a rat model of AD. This systematic review discusses the potential of capsaicin in improving AD pathology and symptoms. A systematic analysis was conducted on the effect of capsaicin on AD-associated molecular changes, cognitive and behaviour resulting in 11 studies employing rodents and/or cell cultures, which were appraised with the Cochrane Risk of Bias tool. Ten studies showed capsaicin attenuated tau deposition, apoptosis, and synaptic dysfunction; was only weakly effective on oxidative stress; and had conflicting effects on amyloid processing. Eight studies demonstrated improved spatial and working memory, learning, and emotional behaviours in rodents following capsaicin treatment. Overall, capsaicin showed promise in improving AD-associated molecular, cognitive, and behavioural changes in cellular and animal models, and further investigations are recommended to test the readily available bioactive, capsaicin, to treat AD. |
| first_indexed | 2024-03-11T02:21:44Z |
| format | Article |
| id | doaj.art-ab35a7626532434182dd212af9021d6c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:44Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ab35a7626532434182dd212af9021d6c2023-11-18T10:49:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121017610.3390/ijms241210176A Systematic Review of the Effects of Capsaicin on Alzheimer’s DiseaseDeborah Inyang0Tasneem Saumtally1Chinelo Nonyerem Nnadi2Sharmila Devi3Po-Wah So4Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 9NU, UKBasic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 9NU, UKBasic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 9NU, UKBasic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 9NU, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 9NU, UKAlzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterised by cognitive impairment, and amyloid-β plaques and neurofibrillary tau tangles at neuropathology. Capsaicin is a spicy-tasting compound found in chili peppers, with anti-inflammatory, antioxidant, and possible neuroprotective properties. Capsaicin intake has been associated with greater cognitive function in humans, and attenuating aberrant tau hyperphosphorylation in a rat model of AD. This systematic review discusses the potential of capsaicin in improving AD pathology and symptoms. A systematic analysis was conducted on the effect of capsaicin on AD-associated molecular changes, cognitive and behaviour resulting in 11 studies employing rodents and/or cell cultures, which were appraised with the Cochrane Risk of Bias tool. Ten studies showed capsaicin attenuated tau deposition, apoptosis, and synaptic dysfunction; was only weakly effective on oxidative stress; and had conflicting effects on amyloid processing. Eight studies demonstrated improved spatial and working memory, learning, and emotional behaviours in rodents following capsaicin treatment. Overall, capsaicin showed promise in improving AD-associated molecular, cognitive, and behavioural changes in cellular and animal models, and further investigations are recommended to test the readily available bioactive, capsaicin, to treat AD.https://www.mdpi.com/1422-0067/24/12/10176capsaicinAlzheimer’s Diseasecognitionamyloidtauchilli peppers |
| spellingShingle | Deborah Inyang Tasneem Saumtally Chinelo Nonyerem Nnadi Sharmila Devi Po-Wah So A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease International Journal of Molecular Sciences capsaicin Alzheimer’s Disease cognition amyloid tau chilli peppers |
| title | A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease |
| title_full | A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease |
| title_fullStr | A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease |
| title_full_unstemmed | A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease |
| title_short | A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease |
| title_sort | systematic review of the effects of capsaicin on alzheimer s disease |
| topic | capsaicin Alzheimer’s Disease cognition amyloid tau chilli peppers |
| url | https://www.mdpi.com/1422-0067/24/12/10176 |
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