Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses

Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses

IntroductionEKLF/Klf1 is a tissue-restricted transcription factor that plays a critical role in all aspects of erythropoiesis. Of particular note is its tissue-restricted pattern of expression, a property that could prove useful for expression control of a linked marker or enzymatic gene.Methods and...

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Bibliographic Details
Main Authors: Li Xue, Kaustav Mukherjee, Kevin A. Kelley, James J. Bieker
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Hematology
Subjects:
CRE/LoxP
EKLF/KLF1
fetal liver
bone marrow
erythroid cells
macrophage cells
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2023.1292589/full

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