Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

Hyperammonemia impairs long-term potentiation (LTP) in hippocampus, by an unknown mechanism. LTP in hippocampal slices requires activation of the soluble guanylate cyclase (sGC)-protein kinase G (PKG)-cGMP-degrading phosphodiesterase pathway. The aim of this work was to assess whether hyperammonemia...

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Bibliographic Details
Main Authors: Pilar Monfort, Marı́a-Dolores Muñoz, Vicente Felipo
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Neurobiology of Disease
Subjects:
cGMP
Soluble guanylate cyclase
Phosphosdiesterase
cGMP-dependent protein kinase
Nitric oxide
Long-term potentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001979

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