Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies
Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the p...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Jambi
2023-07-01
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| Series: | Chempublish Journal |
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| Online Access: | http://online-journal.unja.ac.id/chp/article/view/23726 |
| _version_ | 1797767046731137024 |
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| author | Muhammad Fikriansyah Nelson Madyawati Latief Indra Lasmana Tarigan |
| author_facet | Muhammad Fikriansyah Nelson Madyawati Latief Indra Lasmana Tarigan |
| author_sort | Muhammad Fikriansyah |
| collection | DOAJ |
| description |
Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.
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| first_indexed | 2024-03-12T20:33:30Z |
| format | Article |
| id | doaj.art-ab3799e0520d4a0093d2119f24716421 |
| institution | Directory Open Access Journal |
| issn | 2503-4588 |
| language | Indonesian |
| last_indexed | 2024-03-12T20:33:30Z |
| publishDate | 2023-07-01 |
| publisher | Universitas Jambi |
| record_format | Article |
| series | Chempublish Journal |
| spelling | doaj.art-ab3799e0520d4a0093d2119f247164212023-08-01T16:54:06ZindUniversitas JambiChempublish Journal2503-45882023-07-017110.22437/chp.v7i1.23726Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction StudiesMuhammad Fikriansyah0Nelson1Madyawati Latief2Indra Lasmana Tarigan3Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, Muara Jambi 36361, JambiDepartment of Chemical Analyst, Faculty of Science and Technology, Universitas Jambi, Muara Jambi 36361, JambiDepartment of Chemistry, Faculty of Science and Technology, Universitas Jambi, Muara Jambi 36361, JambiDepartment of Chemistry, Faculty of Science and Technology, Universitas Jambi, Muara Jambi 36361, Jambi Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase. http://online-journal.unja.ac.id/chp/article/view/23726anticancerperoneminsPeronema canescens Jack |
| spellingShingle | Muhammad Fikriansyah Nelson Madyawati Latief Indra Lasmana Tarigan Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies Chempublish Journal anticancer peronemins Peronema canescens Jack |
| title | Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies |
| title_full | Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies |
| title_fullStr | Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies |
| title_full_unstemmed | Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies |
| title_short | Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies |
| title_sort | anticancer activities of seven peronemins a2 a3 b1 b2 b3 c1 and d1 from peronema canescens jack a prediction studies |
| topic | anticancer peronemins Peronema canescens Jack |
| url | http://online-journal.unja.ac.id/chp/article/view/23726 |
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