Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects
The eye is a complex organ consisting of several protective barriers and particular defense mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual impairments it is essential to provide necessary drugs through the appropriate delivery routes and vehicles. The to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/6/1191 |
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| author | Saliha Durak Monireh Esmaeili Rad Abuzer Alp Yetisgin Hande Eda Sutova Ozlem Kutlu Sibel Cetinel Ali Zarrabi |
| author_facet | Saliha Durak Monireh Esmaeili Rad Abuzer Alp Yetisgin Hande Eda Sutova Ozlem Kutlu Sibel Cetinel Ali Zarrabi |
| author_sort | Saliha Durak |
| collection | DOAJ |
| description | The eye is a complex organ consisting of several protective barriers and particular defense mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual impairments it is essential to provide necessary drugs through the appropriate delivery routes and vehicles. The topical route of administration, as the most commonly used approach, maybe inefficient due to low drug bioavailability. New generation safe, effective, and targeted drug delivery systems based on nanocarriers have the capability to circumvent limitations associated with the complex anatomy of the eye. Nanotechnology, through various nanoparticles like niosomes, liposomes, micelles, dendrimers, and different polymeric vesicles play an active role in ophthalmology and ocular drug delivery systems. Niosomes, which are nano-vesicles composed of non-ionic surfactants, are emerging nanocarriers in drug delivery applications due to their solution/storage stability and cost-effectiveness. Additionally, they are biocompatible, biodegradable, flexible in structure, and suitable for loading both hydrophobic and hydrophilic drugs. These characteristics make niosomes promising nanocarriers in the treatment of ocular diseases. Hereby, we review niosome based drug delivery approaches in ophthalmology starting with different preparation methods of niosomes, drug loading/release mechanisms, characterization techniques of niosome nanocarriers and eventually successful applications in the treatment of ocular disorders. |
| first_indexed | 2024-03-10T19:03:26Z |
| format | Article |
| id | doaj.art-ab3812184c474345a20e799b0f927425 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T19:03:26Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ab3812184c474345a20e799b0f9274252023-11-20T04:15:53ZengMDPI AGNanomaterials2079-49912020-06-01106119110.3390/nano10061191Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future ProspectsSaliha Durak0Monireh Esmaeili Rad1Abuzer Alp Yetisgin2Hande Eda Sutova3Ozlem Kutlu4Sibel Cetinel5Ali Zarrabi6Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyThe eye is a complex organ consisting of several protective barriers and particular defense mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual impairments it is essential to provide necessary drugs through the appropriate delivery routes and vehicles. The topical route of administration, as the most commonly used approach, maybe inefficient due to low drug bioavailability. New generation safe, effective, and targeted drug delivery systems based on nanocarriers have the capability to circumvent limitations associated with the complex anatomy of the eye. Nanotechnology, through various nanoparticles like niosomes, liposomes, micelles, dendrimers, and different polymeric vesicles play an active role in ophthalmology and ocular drug delivery systems. Niosomes, which are nano-vesicles composed of non-ionic surfactants, are emerging nanocarriers in drug delivery applications due to their solution/storage stability and cost-effectiveness. Additionally, they are biocompatible, biodegradable, flexible in structure, and suitable for loading both hydrophobic and hydrophilic drugs. These characteristics make niosomes promising nanocarriers in the treatment of ocular diseases. Hereby, we review niosome based drug delivery approaches in ophthalmology starting with different preparation methods of niosomes, drug loading/release mechanisms, characterization techniques of niosome nanocarriers and eventually successful applications in the treatment of ocular disorders.https://www.mdpi.com/2079-4991/10/6/1191niosomenanocarrierocular drug deliveryeye disease |
| spellingShingle | Saliha Durak Monireh Esmaeili Rad Abuzer Alp Yetisgin Hande Eda Sutova Ozlem Kutlu Sibel Cetinel Ali Zarrabi Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects Nanomaterials niosome nanocarrier ocular drug delivery eye disease |
| title | Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
| title_full | Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
| title_fullStr | Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
| title_full_unstemmed | Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
| title_short | Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects |
| title_sort | niosomal drug delivery systems for ocular disease recent advances and future prospects |
| topic | niosome nanocarrier ocular drug delivery eye disease |
| url | https://www.mdpi.com/2079-4991/10/6/1191 |
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