Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development
Human and animal organisms are in a state of low-grade inflammation caused by low concentrations of LPS. The novel potential probiotic Rummeliibacillus stabekisii CY2 was pre-proven in vitro to reduce LPS. Explored its effect in vivo, chicks were fed in different groups (0, CY2L, and CY2H). Results...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001834 |
| _version_ | 1797819903734972416 |
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| author | Weizhe Chen Liyu Du Changyu Cai Lingzhu Huang Qikai Zheng Junjie Chen Linhao Wang Xiangbin Zhang Xiang Fang Li Wang Qingping Zhong Wujie Zhong Jie Wang Zhenlin Liao |
| author_facet | Weizhe Chen Liyu Du Changyu Cai Lingzhu Huang Qikai Zheng Junjie Chen Linhao Wang Xiangbin Zhang Xiang Fang Li Wang Qingping Zhong Wujie Zhong Jie Wang Zhenlin Liao |
| author_sort | Weizhe Chen |
| collection | DOAJ |
| description | Human and animal organisms are in a state of low-grade inflammation caused by low concentrations of LPS. The novel potential probiotic Rummeliibacillus stabekisii CY2 was pre-proven in vitro to reduce LPS. Explored its effect in vivo, chicks were fed in different groups (0, CY2L, and CY2H). Results showed that CY2H had significantly lower serum levels of LPS and the inflammatory factors IL-1 and IL-6, reduced low-grade inflammatory levels, and significantly higher levels of the inflammatory inhibitory factor IL-10. The structure of the chicks’ intestinal microbiota was improved. The relative abundance of the potentially probiotic Lactobacillales increased significantly. Importantly, the growth performance of chicks has been significantly improved. In conclusion, CY2 supplementation can improve immunity through the degradation of LPS, alleviate low-grade inflammation, improve intestinal microbiota, and thus promote the growth of the chicks. |
| first_indexed | 2024-03-13T09:29:26Z |
| format | Article |
| id | doaj.art-ab390e83b48241eeb366a15058078a28 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T09:29:26Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ab390e83b48241eeb366a15058078a282023-05-26T04:21:17ZengElsevierJournal of Functional Foods1756-46462023-06-01105105583Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and developmentWeizhe Chen0Liyu Du1Changyu Cai2Lingzhu Huang3Qikai Zheng4Junjie Chen5Linhao Wang6Xiangbin Zhang7Xiang Fang8Li Wang9Qingping Zhong10Wujie Zhong11Jie Wang12Zhenlin Liao13College of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, China; Kingmed Center for Clinical Laboratory Co., Ltd, Guangzhou 510330, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, China; Corresponding author at: College of Food Science, SCAU, 483 Wushan Rd, Tianhe District, Guangzhou, Guangdong Province, China.Human and animal organisms are in a state of low-grade inflammation caused by low concentrations of LPS. The novel potential probiotic Rummeliibacillus stabekisii CY2 was pre-proven in vitro to reduce LPS. Explored its effect in vivo, chicks were fed in different groups (0, CY2L, and CY2H). Results showed that CY2H had significantly lower serum levels of LPS and the inflammatory factors IL-1 and IL-6, reduced low-grade inflammatory levels, and significantly higher levels of the inflammatory inhibitory factor IL-10. The structure of the chicks’ intestinal microbiota was improved. The relative abundance of the potentially probiotic Lactobacillales increased significantly. Importantly, the growth performance of chicks has been significantly improved. In conclusion, CY2 supplementation can improve immunity through the degradation of LPS, alleviate low-grade inflammation, improve intestinal microbiota, and thus promote the growth of the chicks.http://www.sciencedirect.com/science/article/pii/S1756464623001834Rummeliibacillus stabekisiiImmunityLipopolysaccharideIntestinal microbiotaGrowth performance |
| spellingShingle | Weizhe Chen Liyu Du Changyu Cai Lingzhu Huang Qikai Zheng Junjie Chen Linhao Wang Xiangbin Zhang Xiang Fang Li Wang Qingping Zhong Wujie Zhong Jie Wang Zhenlin Liao Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development Journal of Functional Foods Rummeliibacillus stabekisii Immunity Lipopolysaccharide Intestinal microbiota Growth performance |
| title | Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development |
| title_full | Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development |
| title_fullStr | Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development |
| title_full_unstemmed | Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development |
| title_short | Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development |
| title_sort | take chicks as an example rummeliibacillus stabekisii cy2 enhances immunity and regulates intestinal microbiota by degrading lps to promote organism growth and development |
| topic | Rummeliibacillus stabekisii Immunity Lipopolysaccharide Intestinal microbiota Growth performance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001834 |
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