The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction
Ischemic heart disease resulting from a myocardial infarction (MI), is a major health issue. Stem cell therapies may play an important role in this field. However, cardiomyocytes induced from stem cells are characterized by low rates of differentiation and immaturity. After transplantation into t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2021-12-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://rcm.imrpress.com/EN/10.31083/j.rcm2204125 |
| Summary: | Ischemic heart disease resulting from a myocardial infarction (MI), is a major
health issue. Stem cell therapies may play an important role in this field.
However, cardiomyocytes induced from stem cells are characterized by low rates of
differentiation and immaturity. After transplantation into the damaged heart,
they may even increase the risk of arrhythmias. Studies have demonstrated that
electrical stimulation (ES) can promote the cardiac differentiation of stem
cells. This review summarizes the latest research on the effects of applying
different electrical stimulation (ES) parameters to different types of stem cells
and the related mechanisms that may be involved. |
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| ISSN: | 2153-8174 |