The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction
Ischemic heart disease resulting from a myocardial infarction (MI), is a major health issue. Stem cell therapies may play an important role in this field. However, cardiomyocytes induced from stem cells are characterized by low rates of differentiation and immaturity. After transplantation into t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2021-12-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://rcm.imrpress.com/EN/10.31083/j.rcm2204125 |
| _version_ | 1818491094411771904 |
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| author | Yue Dai Junsheng Mu Fan Zhou |
| author_facet | Yue Dai Junsheng Mu Fan Zhou |
| author_sort | Yue Dai |
| collection | DOAJ |
| description | Ischemic heart disease resulting from a myocardial infarction (MI), is a major
health issue. Stem cell therapies may play an important role in this field.
However, cardiomyocytes induced from stem cells are characterized by low rates of
differentiation and immaturity. After transplantation into the damaged heart,
they may even increase the risk of arrhythmias. Studies have demonstrated that
electrical stimulation (ES) can promote the cardiac differentiation of stem
cells. This review summarizes the latest research on the effects of applying
different electrical stimulation (ES) parameters to different types of stem cells
and the related mechanisms that may be involved. |
| first_indexed | 2024-12-10T17:25:42Z |
| format | Article |
| id | doaj.art-ab39f0e24d294e88bab88abb177dae02 |
| institution | Directory Open Access Journal |
| issn | 2153-8174 |
| language | English |
| last_indexed | 2024-12-10T17:25:42Z |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-ab39f0e24d294e88bab88abb177dae022022-12-22T01:39:51ZengIMR PressReviews in Cardiovascular Medicine2153-81742021-12-012241167117110.31083/j.rcm2204125S1530-6550(21)00231-3The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarctionYue Dai0Junsheng Mu1Fan Zhou2Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, 100029 Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, 100029 Beijing, ChinaDepartment of Ultrasound, The Third Medical Center of PLA General Hospital, 100039 Beijing, ChinaIschemic heart disease resulting from a myocardial infarction (MI), is a major health issue. Stem cell therapies may play an important role in this field. However, cardiomyocytes induced from stem cells are characterized by low rates of differentiation and immaturity. After transplantation into the damaged heart, they may even increase the risk of arrhythmias. Studies have demonstrated that electrical stimulation (ES) can promote the cardiac differentiation of stem cells. This review summarizes the latest research on the effects of applying different electrical stimulation (ES) parameters to different types of stem cells and the related mechanisms that may be involved.https://rcm.imrpress.com/EN/10.31083/j.rcm2204125electrical stimulationstem cellsmyocardial infarctioncardiac differentiation |
| spellingShingle | Yue Dai Junsheng Mu Fan Zhou The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction Reviews in Cardiovascular Medicine electrical stimulation stem cells myocardial infarction cardiac differentiation |
| title | The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| title_full | The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| title_fullStr | The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| title_full_unstemmed | The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| title_short | The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| title_sort | use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction |
| topic | electrical stimulation stem cells myocardial infarction cardiac differentiation |
| url | https://rcm.imrpress.com/EN/10.31083/j.rcm2204125 |
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