The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study
Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnanc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2017-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/6/4/253.full |
| _version_ | 1819038888165900288 |
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| author | Anette Lundqvist Herbert Sandström Torbjörn Bäckström |
| author_facet | Anette Lundqvist Herbert Sandström Torbjörn Bäckström |
| author_sort | Anette Lundqvist |
| collection | DOAJ |
| description | Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a
progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans.
Design: A longitudinal, cohort study.
Methods: Pregnant women (n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35.
Results: Weight increase correlated significantly to allopregnanolone in late pregnancy increase (rs = 0.320; P = 0.016), indicating a positive relationship between weight increase
and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained ≥11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased <11 kg (P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy.
Conclusions: The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations. |
| first_indexed | 2024-12-21T08:44:28Z |
| format | Article |
| id | doaj.art-ab3bbe2cc5df45b4ac480a3b15cf19a0 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-21T08:44:28Z |
| publishDate | 2017-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-ab3bbe2cc5df45b4ac480a3b15cf19a02022-12-21T19:09:52ZengBioscientificaEndocrine Connections2049-36142049-36142017-05-016425325910.1530/EC-17-0046The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal studyAnette Lundqvist0Herbert Sandström1Torbjörn Bäckström2Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, SwedenDepartment of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, SwedenDepartment of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, SwedenObjective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design: A longitudinal, cohort study. Methods: Pregnant women (n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results: Weight increase correlated significantly to allopregnanolone in late pregnancy increase (rs = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained ≥11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased <11 kg (P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions: The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations.http://www.endocrineconnections.com/content/6/4/253.fullallopregnanolonepregnancyweight increaselongitudinal |
| spellingShingle | Anette Lundqvist Herbert Sandström Torbjörn Bäckström The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study Endocrine Connections allopregnanolone pregnancy weight increase longitudinal |
| title | The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
| title_full | The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
| title_fullStr | The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
| title_full_unstemmed | The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
| title_short | The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study |
| title_sort | relationship between weight gain during pregnancy and allopregnanolone levels a longitudinal study |
| topic | allopregnanolone pregnancy weight increase longitudinal |
| url | http://www.endocrineconnections.com/content/6/4/253.full |
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