Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis

Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis

BackgroundThe UNC13A gene is an established susceptibility locus for amyotrophic lateral sclerosis (ALS) and a determinant of shorter survival after disease onset, with up to 33.0 months difference in life expectancy for carriers of the rs12608932 risk genotype. However, its overall effect on other...

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Main Authors: Arianna Manini, Valeria Casiraghi, Alberto Brusati, Alessio Maranzano, Francesco Gentile, Eleonora Colombo, Ruggero Bonetti, Silvia Peverelli, Sabrina Invernizzi, Davide Gentilini, Stefano Messina, Federico Verde, Barbara Poletti, Isabella Fogh, Claudia Morelli, Vincenzo Silani, Antonia Ratti, Nicola Ticozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyotrophic lateral sclerosis
UNC13A
alleles
genotype
motor neurons
behavioral symptoms
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1067954/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1067954/full

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