Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy
The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate au...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1386076/full |
| _version_ | 1827293941868789760 |
|---|---|
| author | Yining Tao Yining Tao Leike Li Xiyu Yang Xiyu Yang Shiyu Yin Shiyu Yin Zhanxiang Zhang Haoyu Wang Haoyu Wang Ruochen Pu Ruochen Pu Zongyi Wang Zongyi Wang Qi Zhang Haoran Mu Haoran Mu Chenqiong Wu Jin He Jin He Liu Yang Liu Yang |
| author_facet | Yining Tao Yining Tao Leike Li Xiyu Yang Xiyu Yang Shiyu Yin Shiyu Yin Zhanxiang Zhang Haoyu Wang Haoyu Wang Ruochen Pu Ruochen Pu Zongyi Wang Zongyi Wang Qi Zhang Haoran Mu Haoran Mu Chenqiong Wu Jin He Jin He Liu Yang Liu Yang |
| author_sort | Yining Tao |
| collection | DOAJ |
| description | The advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications. |
| first_indexed | 2024-04-24T13:47:25Z |
| format | Article |
| id | doaj.art-ab3c243f1b0840b4ac27aafb826f3d6b |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-24T13:47:25Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-ab3c243f1b0840b4ac27aafb826f3d6b2024-04-04T05:07:46ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-04-011210.3389/fchem.2024.13860761386076Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategyYining Tao0Yining Tao1Leike Li2Xiyu Yang3Xiyu Yang4Shiyu Yin5Shiyu Yin6Zhanxiang Zhang7Haoyu Wang8Haoyu Wang9Ruochen Pu10Ruochen Pu11Zongyi Wang12Zongyi Wang13Qi Zhang14Haoran Mu15Haoran Mu16Chenqiong Wu17Jin He18Jin He19Liu Yang20Liu Yang21Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaCommunity Health Service Center, Shanghai, ChinaState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaJintan Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu Province, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaDepartment of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaJintan Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu Province, ChinaDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Bone Tumor Institution, Shanghai, ChinaThe advancements in the field of micro-robots for drug delivery systems have garnered considerable attention. In contrast to traditional drug delivery systems, which are dependent on blood circulation to reach their target, these engineered micro/nano robots possess the unique ability to navigate autonomously, thereby enabling the delivery of drugs to otherwise inaccessible regions. Precise drug delivery systems can improve the effectiveness and safety of synthetic lethality strategies, which are used for targeted therapy of solid tumors. MYC-overexpressing tumors show sensitivity to CDK1 inhibition. This study delves into the potential of Ro-3306 loaded magnetic-driven hydrogel micro-robots in the treatment of MYC-dependent osteosarcoma. Ro-3306, a specific inhibitor of CDK1, has been demonstrated to suppress tumor growth across various types of cancer. We have designed and fabricated this micro-robot, capable of delivering Ro-3306 precisely to tumor cells under the influence of a magnetic field, and evaluated its chemosensitizing effects, thereby augmenting the therapeutic efficacy and introducing a novel possibility for osteosarcoma treatment. The clinical translation of this method necessitates further investigation and validation. In summary, the Ro-3306-loaded magnetic-driven hydrogel micro-robots present a novel strategy for enhancing the chemosensitivity of MYC-dependent osteosarcoma, paving the way for new possibilities in future clinical applications.https://www.frontiersin.org/articles/10.3389/fchem.2024.1386076/fullmicrorobotsmagnetic-drivendrug delivery systemMYCsynthetic lethalityosteosarcoma |
| spellingShingle | Yining Tao Yining Tao Leike Li Xiyu Yang Xiyu Yang Shiyu Yin Shiyu Yin Zhanxiang Zhang Haoyu Wang Haoyu Wang Ruochen Pu Ruochen Pu Zongyi Wang Zongyi Wang Qi Zhang Haoran Mu Haoran Mu Chenqiong Wu Jin He Jin He Liu Yang Liu Yang Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy Frontiers in Chemistry microrobots magnetic-driven drug delivery system MYC synthetic lethality osteosarcoma |
| title | Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy |
| title_full | Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy |
| title_fullStr | Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy |
| title_full_unstemmed | Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy |
| title_short | Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy |
| title_sort | magnetic driven hydrogel microrobots for promoting osteosarcoma chemo therapy with synthetic lethality strategy |
| topic | microrobots magnetic-driven drug delivery system MYC synthetic lethality osteosarcoma |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1386076/full |
| work_keys_str_mv | AT yiningtao magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT yiningtao magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT leikeli magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT xiyuyang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT xiyuyang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT shiyuyin magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT shiyuyin magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT zhanxiangzhang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT haoyuwang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT haoyuwang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT ruochenpu magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT ruochenpu magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT zongyiwang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT zongyiwang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT qizhang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT haoranmu magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT haoranmu magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT chenqiongwu magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT jinhe magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT jinhe magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT liuyang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy AT liuyang magneticdrivenhydrogelmicrorobotsforpromotingosteosarcomachemotherapywithsyntheticlethalitystrategy |