Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases
Urolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating studies have reported its multiple potential health benefits in a broad range of diseases, including cardiovascular...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/12/2549 |
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| author | Kailin Li Yao Xiao Ji Bian Lin Han Caian He Emad El-Omar Lan Gong Min Wang |
| author_facet | Kailin Li Yao Xiao Ji Bian Lin Han Caian He Emad El-Omar Lan Gong Min Wang |
| author_sort | Kailin Li |
| collection | DOAJ |
| description | Urolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating studies have reported its multiple potential health benefits in a broad range of diseases, including cardiovascular disease, cancer, cognitive impairment, and diabetes. In particular, Uro A is safe via direct oral administration and is non-genotoxic. The pancreas plays a central role in regulating energy consumption and metabolism by secreting digestive enzymes and hormones. Numerous pathophysiological factors, such as inflammation, deficits of mitophagy, and endoplasmic reticulum stress, can negatively affect the pancreas, leading to pancreatic diseases, including pancreatitis, pancreatic cancer, and diabetes mellitus. Recent studies showed that Uro A activates autophagy and inhibits endoplasmic reticulum stress in the pancreas, thus decreasing oxidative stress, inflammation, and apoptosis. In this review, we summarize the knowledge of Uro A metabolism and biological activity in the gut, as well as the pathological features and mechanisms of common pancreatic diseases. Importantly, we focus on the potential activities of Uro A and the underlying mechanisms in ameliorating various pancreatic diseases via inhibiting inflammatory signaling pathways, activating autophagy, maintaining the mitochondrial function, and improving the immune microenvironment. It might present a novel nutritional strategy for the intervention and prevention of pancreatic diseases. |
| first_indexed | 2024-03-09T22:49:39Z |
| format | Article |
| id | doaj.art-ab3ca1020c4a4c18b4b9a96e2a4d9709 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:49:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ab3ca1020c4a4c18b4b9a96e2a4d97092023-11-23T18:23:05ZengMDPI AGNutrients2072-66432022-06-011412254910.3390/nu14122549Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic DiseasesKailin Li0Yao Xiao1Ji Bian2Lin Han3Caian He4Emad El-Omar5Lan Gong6Min Wang7College of Food Science and Engineering, Northwest A&F University, Xianyang 712100, ChinaCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, ChinaKolling Institute, Sydney Medical School, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, AustraliaCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, ChinaCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, ChinaMicrobiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW 2052, AustraliaMicrobiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW 2052, AustraliaCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, ChinaUrolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating studies have reported its multiple potential health benefits in a broad range of diseases, including cardiovascular disease, cancer, cognitive impairment, and diabetes. In particular, Uro A is safe via direct oral administration and is non-genotoxic. The pancreas plays a central role in regulating energy consumption and metabolism by secreting digestive enzymes and hormones. Numerous pathophysiological factors, such as inflammation, deficits of mitophagy, and endoplasmic reticulum stress, can negatively affect the pancreas, leading to pancreatic diseases, including pancreatitis, pancreatic cancer, and diabetes mellitus. Recent studies showed that Uro A activates autophagy and inhibits endoplasmic reticulum stress in the pancreas, thus decreasing oxidative stress, inflammation, and apoptosis. In this review, we summarize the knowledge of Uro A metabolism and biological activity in the gut, as well as the pathological features and mechanisms of common pancreatic diseases. Importantly, we focus on the potential activities of Uro A and the underlying mechanisms in ameliorating various pancreatic diseases via inhibiting inflammatory signaling pathways, activating autophagy, maintaining the mitochondrial function, and improving the immune microenvironment. It might present a novel nutritional strategy for the intervention and prevention of pancreatic diseases.https://www.mdpi.com/2072-6643/14/12/2549urolithin Apancreasautophagymicrobiotadiet |
| spellingShingle | Kailin Li Yao Xiao Ji Bian Lin Han Caian He Emad El-Omar Lan Gong Min Wang Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases Nutrients urolithin A pancreas autophagy microbiota diet |
| title | Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases |
| title_full | Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases |
| title_fullStr | Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases |
| title_full_unstemmed | Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases |
| title_short | Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases |
| title_sort | ameliorative effects of gut microbial metabolite urolithin a on pancreatic diseases |
| topic | urolithin A pancreas autophagy microbiota diet |
| url | https://www.mdpi.com/2072-6643/14/12/2549 |
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