The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia
Objective The aim of the present study was to detect the association between platelet glycoprotein-specific autoantibodies and the patient response to short-term high-dose dexamethasone (HD-DXM) + prednisone maintenance treatment. Methods The data from 112 adult patients newly diagnosed with ITP who...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Annals of Medicine |
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| Online Access: | http://dx.doi.org/10.1080/07853890.2021.2018486 |
| _version_ | 1828127003222474752 |
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| author | Yan-Qiu Hou Yan Wang Chang-Xun Liu Shu-Xia Li Ya-Lan Peng Wang Dong-Dong Ru-La Sa |
| author_facet | Yan-Qiu Hou Yan Wang Chang-Xun Liu Shu-Xia Li Ya-Lan Peng Wang Dong-Dong Ru-La Sa |
| author_sort | Yan-Qiu Hou |
| collection | DOAJ |
| description | Objective The aim of the present study was to detect the association between platelet glycoprotein-specific autoantibodies and the patient response to short-term high-dose dexamethasone (HD-DXM) + prednisone maintenance treatment. Methods The data from 112 adult patients newly diagnosed with ITP who were administered first-line HD-DXM + prednisone maintenance therapy between January 2016 and January 2021 were retrospectively analyzed. Results A total of 72 patients positive for platelet glycoprotein-specific antibodies were enrolled in the antibody-positive group, and 40 patients not positive for platelet glycoprotein-specific antibodies were enrolled in the antibody-negative group. In the antibody-positive group, six platelet glycoprotein-specific antibody types were found: 41.67% of the patients were anti-GP IIb/IIIa-positive only, 5.56% were anti-GP Ib/IX-positive only, 5.56% were anti-P-selectin-positive only, 19.44% were anti-GP IIb/IIIa- and anti-GP Ib/IX-positive, 16.67% were anti-GP Ib/IX- and P-selectin-positive and 11.11% were positive for all three antibodies. There was no significant difference in the overall response rate between the antibody-positive group and the antibody-negative group (94.44 versus 80.00%, p = .221). However, the CR rate was significantly higher in the antibody-positive group than in the antibody-negative group (69.44% versus 40.00%, p = .032). The logistic regression analysis revealed that platelet glycoprotein-specific antibody positivity and age were two factors that could affect patient response. Conclusions The present study discovered that adult patients newly diagnosed with ITP who had positive platelet glycoprotein-specific antibody test results were likely to achieve a better response after treatment with HD-DXM + prednisone maintenance. |
| first_indexed | 2024-04-11T15:43:53Z |
| format | Article |
| id | doaj.art-ab3cc61335f74de5b2ba7a40052ad751 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-11T15:43:53Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-ab3cc61335f74de5b2ba7a40052ad7512022-12-22T04:15:42ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-0154113213710.1080/07853890.2021.20184862018486The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopeniaYan-Qiu Hou0Yan Wang1Chang-Xun Liu2Shu-Xia Li3Ya-Lan Peng4Wang Dong-Dong5Ru-La Sa6Department of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalDepartment of Blood, Hulunbeir People's HospitalObjective The aim of the present study was to detect the association between platelet glycoprotein-specific autoantibodies and the patient response to short-term high-dose dexamethasone (HD-DXM) + prednisone maintenance treatment. Methods The data from 112 adult patients newly diagnosed with ITP who were administered first-line HD-DXM + prednisone maintenance therapy between January 2016 and January 2021 were retrospectively analyzed. Results A total of 72 patients positive for platelet glycoprotein-specific antibodies were enrolled in the antibody-positive group, and 40 patients not positive for platelet glycoprotein-specific antibodies were enrolled in the antibody-negative group. In the antibody-positive group, six platelet glycoprotein-specific antibody types were found: 41.67% of the patients were anti-GP IIb/IIIa-positive only, 5.56% were anti-GP Ib/IX-positive only, 5.56% were anti-P-selectin-positive only, 19.44% were anti-GP IIb/IIIa- and anti-GP Ib/IX-positive, 16.67% were anti-GP Ib/IX- and P-selectin-positive and 11.11% were positive for all three antibodies. There was no significant difference in the overall response rate between the antibody-positive group and the antibody-negative group (94.44 versus 80.00%, p = .221). However, the CR rate was significantly higher in the antibody-positive group than in the antibody-negative group (69.44% versus 40.00%, p = .032). The logistic regression analysis revealed that platelet glycoprotein-specific antibody positivity and age were two factors that could affect patient response. Conclusions The present study discovered that adult patients newly diagnosed with ITP who had positive platelet glycoprotein-specific antibody test results were likely to achieve a better response after treatment with HD-DXM + prednisone maintenance.http://dx.doi.org/10.1080/07853890.2021.2018486primary immune thrombocytopeniaplatelet glycoprotein-specific autoantibodytreatment responsedexamethasoneprednisone |
| spellingShingle | Yan-Qiu Hou Yan Wang Chang-Xun Liu Shu-Xia Li Ya-Lan Peng Wang Dong-Dong Ru-La Sa The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia Annals of Medicine primary immune thrombocytopenia platelet glycoprotein-specific autoantibody treatment response dexamethasone prednisone |
| title | The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| title_full | The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| title_fullStr | The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| title_full_unstemmed | The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| title_short | The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| title_sort | association between platelet glycoprotein specific antibodies and response to short term high dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia |
| topic | primary immune thrombocytopenia platelet glycoprotein-specific autoantibody treatment response dexamethasone prednisone |
| url | http://dx.doi.org/10.1080/07853890.2021.2018486 |
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