Under-Replicated DNA: The Byproduct of Large Genomes?
In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukary...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2764 |
| _version_ | 1797552570481246208 |
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| author | Agustina P. Bertolin Jean-Sébastien Hoffmann Vanesa Gottifredi |
| author_facet | Agustina P. Bertolin Jean-Sébastien Hoffmann Vanesa Gottifredi |
| author_sort | Agustina P. Bertolin |
| collection | DOAJ |
| description | In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1-NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle. |
| first_indexed | 2024-03-10T16:02:59Z |
| format | Article |
| id | doaj.art-ab3d4743283b4474ba52fc69e95d6635 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:02:59Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ab3d4743283b4474ba52fc69e95d66352023-11-20T15:08:07ZengMDPI AGCancers2072-66942020-09-011210276410.3390/cancers12102764Under-Replicated DNA: The Byproduct of Large Genomes?Agustina P. Bertolin0Jean-Sébastien Hoffmann1Vanesa Gottifredi2Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKLaboratoire D’Excellence Toulouse Cancer (TOUCAN), Laboratoire de Pathologie, Institut Universitaire du Cancer-Toulouse, Oncopole, 1 avenue Irène-Joliot-Curie, 31059 Toulouse Cedex, FranceFundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, C1405 BWE Buenos Aires, ArgentinaIn this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1-NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle.https://www.mdpi.com/2072-6694/12/10/2764DNA replication stresscommon fragile sites (CFS)double fork stalling (DFS)under-replicated DNA (UR-DNA)mitotic DNA synthesis (MiDAS)53BP1 |
| spellingShingle | Agustina P. Bertolin Jean-Sébastien Hoffmann Vanesa Gottifredi Under-Replicated DNA: The Byproduct of Large Genomes? Cancers DNA replication stress common fragile sites (CFS) double fork stalling (DFS) under-replicated DNA (UR-DNA) mitotic DNA synthesis (MiDAS) 53BP1 |
| title | Under-Replicated DNA: The Byproduct of Large Genomes? |
| title_full | Under-Replicated DNA: The Byproduct of Large Genomes? |
| title_fullStr | Under-Replicated DNA: The Byproduct of Large Genomes? |
| title_full_unstemmed | Under-Replicated DNA: The Byproduct of Large Genomes? |
| title_short | Under-Replicated DNA: The Byproduct of Large Genomes? |
| title_sort | under replicated dna the byproduct of large genomes |
| topic | DNA replication stress common fragile sites (CFS) double fork stalling (DFS) under-replicated DNA (UR-DNA) mitotic DNA synthesis (MiDAS) 53BP1 |
| url | https://www.mdpi.com/2072-6694/12/10/2764 |
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