Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity d...

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Bibliographic Details
Main Authors: Paula Abal, M. Carmen Louzao, Alvaro Antelo, Mercedes Alvarez, Eva Cagide, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Toxins
Subjects:
acute oral toxicity
European molluscs
lethal dose 50 (LD50)
No Observed Adverse Effect Level (NOAEL)
risk assessment
tetrodotoxin
Online Access:http://www.mdpi.com/2072-6651/9/3/75

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