Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications
Ezrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1125881/full |
| _version_ | 1811158460570533888 |
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| author | Wen-Ting Xu Ling-Li Shi Jie Xu Haiqing Qian Huifang Zhou Li-Hong Wang |
| author_facet | Wen-Ting Xu Ling-Li Shi Jie Xu Haiqing Qian Huifang Zhou Li-Hong Wang |
| author_sort | Wen-Ting Xu |
| collection | DOAJ |
| description | Ezrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation. We reviewed the recent studies on the modalities of ezrin regulation and its involvement in the biological processes of female reproductive physiology and summarized the current research advances in ezrin inhibitors. These studies will provide new strategies and insights for the treatment of diseases. |
| first_indexed | 2024-04-10T05:23:58Z |
| format | Article |
| id | doaj.art-ab400debbadd450187ea230c91401f21 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T05:23:58Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ab400debbadd450187ea230c91401f212023-03-08T04:30:17ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-03-011110.3389/fcell.2023.11258811125881Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implicationsWen-Ting Xu0Ling-Li Shi1Jie Xu2Haiqing Qian3Huifang Zhou4Li-Hong Wang5Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, ChinaDepartment of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, ChinaTranslational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, ChinaDepartment of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, ChinaDepartment of Gynaecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, ChinaEzrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation. We reviewed the recent studies on the modalities of ezrin regulation and its involvement in the biological processes of female reproductive physiology and summarized the current research advances in ezrin inhibitors. These studies will provide new strategies and insights for the treatment of diseases.https://www.frontiersin.org/articles/10.3389/fcell.2023.1125881/fullezrinfemale reproductiveembryooocytesfollicle |
| spellingShingle | Wen-Ting Xu Ling-Li Shi Jie Xu Haiqing Qian Huifang Zhou Li-Hong Wang Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications Frontiers in Cell and Developmental Biology ezrin female reproductive embryo oocytes follicle |
| title | Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications |
| title_full | Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications |
| title_fullStr | Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications |
| title_full_unstemmed | Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications |
| title_short | Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications |
| title_sort | ezrin expression in female reproductive tissues a review of regulation and pathophysiological implications |
| topic | ezrin female reproductive embryo oocytes follicle |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1125881/full |
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