Association of the genetic markers for myocardial infarction with sudden cardiac death
Objective: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the internati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Indian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483216303303 |
| _version_ | 1819283551129960448 |
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| author | Anastasiya A. Ivanova Vladimir N. Maksimov Pavel S. Orlov Dinara E. Ivanoshchuk Sergei V. Savchenko Mikhail I. Voevoda |
| author_facet | Anastasiya A. Ivanova Vladimir N. Maksimov Pavel S. Orlov Dinara E. Ivanoshchuk Sergei V. Savchenko Mikhail I. Voevoda |
| author_sort | Anastasiya A. Ivanova |
| collection | DOAJ |
| description | Objective: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the international genome-wide studies with sudden cardiac death (SCD) in a case–control study.
Methods: A sample of SCD cases (n = 285) was formed using the WHO criteria; the control sample (n = 421) was selected according to sex and age. DNA was isolated by phenol–chloroform extraction from the myocardial tissue of SCD cases and blood of control cases. The groups were genotyped for the selected SNPs by real-time PCR using TaqMan probes (Applied Biosystems, United States).
Results: No statistically significant differences in the genotype and allelic frequencies of studied single nucleotide polymorphisms between sudden cardiac death cases and control were detectable in general group. By separating the groups of sex and age differences in the genotype frequencies of rs1333049, rs10757278 and rs499818 are statistical significance. Genotypes CC of rs1333049 and GG of rs10757278 are associated with an increased sudden cardiac death risk in men (p = 0.019, OR = 1.7, 95% CI 1.1–2.8; p = 0.011, OR = 1.8, 95% CI 1.2–2.8, respectively). Genotype AG of rs499818 is associated with an increased sudden cardiac death risk in the women over 50 years old (p = 0.009, OR = 2.4, 95% CI 1.3–4.6).
Conclusion: Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years. |
| first_indexed | 2024-12-24T01:33:16Z |
| format | Article |
| id | doaj.art-ab41c057f0774a70ace721eb0b4f2260 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-24T01:33:16Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-ab41c057f0774a70ace721eb0b4f22602022-12-21T17:22:17ZengElsevierIndian Heart Journal0019-48322017-04-0169S1S8S1110.1016/j.ihj.2016.07.016Association of the genetic markers for myocardial infarction with sudden cardiac deathAnastasiya A. Ivanova0Vladimir N. Maksimov1Pavel S. Orlov2Dinara E. Ivanoshchuk3Sergei V. Savchenko4Mikhail I. Voevoda5Federal State Budgetary of Scientific Institution “Institution of Internal and Preventive Medicine”, Novosibirsk, RussiaFederal State Budgetary of Scientific Institution “Institution of Internal and Preventive Medicine”, Novosibirsk, RussiaFederal State Budgetary of Scientific Institution “Institution of Internal and Preventive Medicine”, Novosibirsk, RussiaFederal State Budgetary of Scientific Institution “Institution of Internal and Preventive Medicine”, Novosibirsk, RussiaNovosibirsk Regional Office of Forensic Medical Examination, Novosibirsk, RussiaFederal State Budgetary of Scientific Institution “Institution of Internal and Preventive Medicine”, Novosibirsk, RussiaObjective: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the international genome-wide studies with sudden cardiac death (SCD) in a case–control study. Methods: A sample of SCD cases (n = 285) was formed using the WHO criteria; the control sample (n = 421) was selected according to sex and age. DNA was isolated by phenol–chloroform extraction from the myocardial tissue of SCD cases and blood of control cases. The groups were genotyped for the selected SNPs by real-time PCR using TaqMan probes (Applied Biosystems, United States). Results: No statistically significant differences in the genotype and allelic frequencies of studied single nucleotide polymorphisms between sudden cardiac death cases and control were detectable in general group. By separating the groups of sex and age differences in the genotype frequencies of rs1333049, rs10757278 and rs499818 are statistical significance. Genotypes CC of rs1333049 and GG of rs10757278 are associated with an increased sudden cardiac death risk in men (p = 0.019, OR = 1.7, 95% CI 1.1–2.8; p = 0.011, OR = 1.8, 95% CI 1.2–2.8, respectively). Genotype AG of rs499818 is associated with an increased sudden cardiac death risk in the women over 50 years old (p = 0.009, OR = 2.4, 95% CI 1.3–4.6). Conclusion: Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years.http://www.sciencedirect.com/science/article/pii/S0019483216303303Sudden cardiac death9p21rs17465637rs1376251rs4804611rs619203rs2549513rs499818 |
| spellingShingle | Anastasiya A. Ivanova Vladimir N. Maksimov Pavel S. Orlov Dinara E. Ivanoshchuk Sergei V. Savchenko Mikhail I. Voevoda Association of the genetic markers for myocardial infarction with sudden cardiac death Indian Heart Journal Sudden cardiac death 9p21 rs17465637 rs1376251 rs4804611 rs619203 rs2549513 rs499818 |
| title | Association of the genetic markers for myocardial infarction with sudden cardiac death |
| title_full | Association of the genetic markers for myocardial infarction with sudden cardiac death |
| title_fullStr | Association of the genetic markers for myocardial infarction with sudden cardiac death |
| title_full_unstemmed | Association of the genetic markers for myocardial infarction with sudden cardiac death |
| title_short | Association of the genetic markers for myocardial infarction with sudden cardiac death |
| title_sort | association of the genetic markers for myocardial infarction with sudden cardiac death |
| topic | Sudden cardiac death 9p21 rs17465637 rs1376251 rs4804611 rs619203 rs2549513 rs499818 |
| url | http://www.sciencedirect.com/science/article/pii/S0019483216303303 |
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